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Risk factors include genetic variation, mitochondrial dysfunction, lifestyle factors, poor gut microbiome health and abnormalities in hunger, satiety, and hedonistic function. Evidence suggests metabolic jet lag is a core component of BD pathophysiology, as individuals with BD frequently exhibit irregular eating rhythms and circadian desynchronization of their energetic metabolism, which is associated with unfavorable clinical outcomes. Although current diagnostic criteria lack any assessment of eating rhythms, technological advancements including mobile phone applications and ecological momentary assessment allow for the reliable tracking of biological rhythms. Overall, methodological refinement of metabolic jet lag assessment will increase knowledge in this field and stimulate the development of interventions targeting metabolic rhythms, such as time-restricted eating.<\/jats:p>","DOI":"10.1017\/s1092852922001195","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T09:44:59Z","timestamp":1670838299000},"page":"571-580","source":"Crossref","is-referenced-by-count":9,"title":["The concept of \u201cmetabolic jet lag\u201d in the pathophysiology of bipolar disorder: implications for research and clinical 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