{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:23:06Z","timestamp":1773872586542,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1092852924000099_sec1\"><jats:title>Background<\/jats:title><jats:p>Post-COVID-19 condition (PCC) is associated with a host of psychopathological conditions including prominent anxiety symptoms. However, it is not known what effect anxious symptoms have on measures of well-being in individuals living with PCC. This study aims to evaluate anxiety\u2019s association with measures of well-being in people with PCC.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924000099_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>This is a post hoc analysis utilizing data from a placebo-controlled, randomized, double-blind clinical trial assessing the effect of vortioxetine on cognitive impairment in individuals with PCC (NCT05047952). Baseline data with respect to anxiety and well-being were collected using the Generalized Anxiety Disorder Scale, 7-Item (GAD-7), and the World Health Organization (WHO) Well-Being Index, 5-Item (WHO-5), respectively. A generalized linear model (GLM) analysis on baseline GAD-7 and WHO-5 scores was conducted with age, sex, employment status, education level, previous major depressive disorder (MDD) diagnosis, and confirmed COVID-19 cases as covariates.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924000099_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Data was analyzed in a sample of 144 participants (<jats:italic>N<\/jats:italic>\u00a0=\u00a0144). After controlling for the aforementioned covariates, the results found that GAD-7 and WHO-5 scores had a significant negative correlation (\u03b2\u00a0=\u00a0\u22120.053, <jats:italic>p<\/jats:italic>\u00a0=\u00a0&lt;0.001), signifying that increased anxiety had adverse effects on the overall well-being of individuals with PCC.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924000099_sec4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>Herein, we observed a clinically meaningful level of anxiety in individuals with PCC. We also identified a robust correlation between anxiety in PCC and measures of general well-being. Our results require replication, providing the impetus for recommending screening and targeting anxious symptoms as a tactic to improve general well-being and outcomes in individuals with PCC.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852924000099","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T03:50:55Z","timestamp":1709869855000},"page":"150-154","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Baseline Anxiety on Well-being in People with Post-COVID-19 Condition: A Secondary Analysis"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1220-3599","authenticated-orcid":false,"given":"Nicholas","family":"Kleine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-1112","authenticated-orcid":false,"given":"Angela 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