{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:26:49Z","timestamp":1785418009633,"version":"3.56.0"},"reference-count":80,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obsessive-compulsive disorder (OCD) is a prevalent condition with multifactorial etiology involving genetic and environmental factors. The present study aims to summarize the correlates of stressful life events (SLEs) in OCD by reviewing studies comparing OCD associated or not with SLEs before its onset. To do so, a systematic review was performed by searching PubMed, Web of Science, Scopus, and PsycINFO databases for studies published between the database\u2019s inception and November 27, 2023. Studies including individuals whose OCD was precipitated or not by SLEs (SLEs OCD and NSLEs OCD, respectively) were assessed. Effect sizes or odds ratios were then calculated to identify the strength of association between SLEs and clinical characteristics, such as gender, age of onset, family history of OCD, severity of OCD symptoms, depressive symptoms, and mood comorbidities among patients with OCD. Out of the 4083 records initially identified, 5 studies met the inclusion criteria and 3 were comparable through a meta-analysis. Notably, the analyses were limited by the small number of studies available in the literature. The meta-analysis demonstrated SLEs OCD to be associated with female gender, later OCD onset, and increased comorbidity rates with mood disorders. Despite the cross-sectional nature of the reviewed studies, women may be more vulnerable to develop a later onset of OCD following SLEs, which may also lead to mood disorders. Caution is needed to avoid prematurely classifying this presentation as a distinct subtype of OCD.<\/jats:p>","DOI":"10.1017\/s1092852924000269","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T04:38:07Z","timestamp":1714451887000},"page":"252-260","source":"Crossref","is-referenced-by-count":5,"title":["Towards the correlates of stressful life events as precipitants of obsessive-compulsive disorder: a systematic review and metanalysis"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-6915","authenticated-orcid":false,"given":"Ver\u00f4nica","family":"H\u00fchne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samara","family":"dos Santos-Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Moreira-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela B.","family":"de Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo F.","family":"Fontenelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"S1092852924000269_r54","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1971.01750160052010"},{"key":"S1092852924000269_r21","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.108.s418.13.x"},{"key":"S1092852924000269_r30","first-page":"11","article-title":"Recent stressful life events in euthymic major depressive disorder patients: sociodemographic and clinical characteristics","author":"Serafini","year":"2020","journal-title":"Front Psychiatry"},{"key":"S1092852924000269_r7","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2013.3"},{"key":"S1092852924000269_r59","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.03.037"},{"key":"S1092852924000269_r56","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852914000777"},{"key":"S1092852924000269_r9","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3746"},{"key":"S1092852924000269_r77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.03.046"},{"key":"S1092852924000269_r5","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760290125015"},{"key":"S1092852924000269_r57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.10.021"},{"key":"S1092852924000269_r55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001617"},{"key":"S1092852924000269_r49","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2012.30"},{"key":"S1092852924000269_r47","doi-asserted-by":"publisher","DOI":"10.1002\/da.20792"},{"key":"S1092852924000269_r40","doi-asserted-by":"publisher","DOI":"10.1177\/1524838011416375"},{"key":"S1092852924000269_r68","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30149"},{"key":"S1092852924000269_r15","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2017.12.006"},{"key":"S1092852924000269_r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2009.11.001"},{"key":"S1092852924000269_r61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.09.019"},{"key":"S1092852924000269_r1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"S1092852924000269_r22","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-5215.2002.140402.x"},{"key":"S1092852924000269_r79","first-page":"182","article-title":"Role of life events in obsessive compulsive disorder","volume":"48","author":"Sarkhel","year":"2011","journal-title":"Isr J Psychiatry Relat Sci."},{"key":"S1092852924000269_r34","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.02.004"},{"key":"S1092852924000269_r33","doi-asserted-by":"publisher","DOI":"10.1159\/000526708"},{"key":"S1092852924000269_r3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.011"},{"key":"S1092852924000269_r58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1614.2004.01397.x"},{"key":"S1092852924000269_r46","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"S1092852924000269_r72","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.05.034"},{"key":"S1092852924000269_r76","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.08.073"},{"key":"S1092852924000269_r53","first-page":"98","article-title":"A rating scale for depression","volume":"38","author":"Hamilton","year":"1960","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"S1092852924000269_r70","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12433"},{"key":"S1092852924000269_r16","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2011.607848"},{"key":"S1092852924000269_r23","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.51.10.1299"},{"key":"S1092852924000269_r28","doi-asserted-by":"publisher","DOI":"10.1111\/psyg.12024"},{"key":"S1092852924000269_r12","doi-asserted-by":"publisher","DOI":"10.1177\/2470547018758043"},{"key":"S1092852924000269_r24","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199811000-00001"},{"key":"S1092852924000269_r39","doi-asserted-by":"publisher","DOI":"10.1007\/s10942-006-0025-2"},{"key":"S1092852924000269_r71","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2062"},{"key":"S1092852924000269_r73","doi-asserted-by":"publisher","DOI":"10.1002\/da.22606"},{"key":"S1092852924000269_r20","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e3181be7841"},{"key":"S1092852924000269_r4","doi-asserted-by":"publisher","DOI":"10.2217\/npy.10.1"},{"key":"S1092852924000269_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.12.001"},{"key":"S1092852924000269_r67","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0435"},{"key":"S1092852924000269_r62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.09.012"},{"key":"S1092852924000269_r45","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15f10150"},{"key":"S1092852924000269_r27","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.207339"},{"key":"S1092852924000269_r37","doi-asserted-by":"publisher","DOI":"10.1080\/21642850.2014.905207"},{"key":"S1092852924000269_r50","doi-asserted-by":"publisher","DOI":"10.3109\/15622975.2016.1142606"},{"key":"S1092852924000269_r14","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.132.3.477"},{"key":"S1092852924000269_r26","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1975.01760210061003"},{"key":"S1092852924000269_r38","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-6185(02)00224-4"},{"key":"S1092852924000269_r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2006.08.018"},{"key":"S1092852924000269_r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2018.08.012"},{"key":"S1092852924000269_r63","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170001429X"},{"key":"S1092852924000269_r64","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.6.837"},{"key":"S1092852924000269_r13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010418-102857"},{"key":"S1092852924000269_r80","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2004.02.010"},{"key":"S1092852924000269_r29","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(01)00479-7"},{"key":"S1092852924000269_r78","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(89)90017-X"},{"key":"S1092852924000269_r52","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(94)00076-V"},{"key":"S1092852924000269_r31","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0b013e318199f77b"},{"key":"S1092852924000269_r19","doi-asserted-by":"publisher","DOI":"10.1002\/da.22907"},{"key":"S1092852924000269_r75","doi-asserted-by":"publisher","DOI":"10.4103\/IJPSYM.IJPSYM_113_18"},{"key":"S1092852924000269_r41","unstructured":"41. Huhne, V , Santos-ribeiro, S , Moreira-de-oliveira, ME , De Menezes, GB , Leonardo, F. International prospective register of systematic reviews: presence of stressful life events[CMT7] in people diagnosed with obsessive compulsive disorder: a systematic review. Citation Review question Participants\/population Intervention (s), exposure (s) C. 2020:1\u20134."},{"key":"S1092852924000269_r48","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2011.10.005"},{"key":"S1092852924000269_r51","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.561266"},{"key":"S1092852924000269_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2011.06.007"},{"key":"S1092852924000269_r42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"S1092852924000269_r36","doi-asserted-by":"publisher","DOI":"10.1037\/int0000050"},{"key":"S1092852924000269_r43","unstructured":"43. Moola, S , Munn, Z , Tufanaru, C , Aromataris, E , Sears, K , Sfetcu, R , Currie, M , Qureshi, R , Mattis, P , KMP-F, Lisy . Checklist for case control studies. In: Aromataris, EMZ , ed. JBI Manual for Evidence Synthesis; 2020. https:\/\/synthesismanual.jbi.global. Accessed 09 February, 2023."},{"key":"S1092852924000269_r32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.02.059"},{"key":"S1092852924000269_r44","doi-asserted-by":"publisher","DOI":"10.1002\/9781119099369.ch27"},{"key":"S1092852924000269_r60","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462002000100005"},{"key":"S1092852924000269_r69","doi-asserted-by":"publisher","DOI":"10.1159\/000056210"},{"key":"S1092852924000269_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2020.07.027"},{"key":"S1092852924000269_r74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.02.036"},{"key":"S1092852924000269_r35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2021.100170"},{"key":"S1092852924000269_r65","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.48.1.191"},{"key":"S1092852924000269_r66","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001591"},{"key":"S1092852924000269_r25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2006.06.011"},{"key":"S1092852924000269_r11","unstructured":"11. American Psychiatric Association. DSM-5 \u2013 Manual Diagn\u00f3stico e Estat\u00edstico de Transtornos Mentais; 2014. niip.com.br\/wp-content\/uploads\/2018\/06\/Manual-Diagnosico-e-Estatistico-de-Transtornos-Mentais-DSM-5-1-. Accessed 30 November, 2020."}],"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1092852924000269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T09:44:14Z","timestamp":1727343854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1092852924000269\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,30]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1092852924000269"],"URL":"https:\/\/doi.org\/10.1017\/s1092852924000269","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,30]]}}}