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Here, we investigate relationships between the baseline shape and volume of subcortical nuclei, diagnosis, and tic symptom outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002190_sec2\" sec-type=\"methods\"><jats:title>Methods<\/jats:title><jats:p>187 children were assessed at baseline and a 12-month follow-up: 88 with NT, 60 tic-free healthy controls (HC), and 39 with chronic tic disorder\/Tourette syndrome (TS), using T1-weighted MRI and total tic scores (TTS) from the Yale Global Tic Severity Scale to evaluate symptom change. Subcortical surface maps were generated using FreeSurfer-initialized large deformation diffeomorphic metric mapping. Linear regression models correlated baseline structural shapes with follow-up TTS while accounting for covariates, with relationships mapped onto structure surfaces.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002190_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>We found that the NT group had a larger right hippocampus compared to HC. Surface maps illustrate distinct patterns of inward deformation in the putamen and outward deformation in the thalamus for NT compared to controls. We also found patterns of outward deformation in almost all studied structures when comparing the TS group to controls. The NT group also showed consistent outward deformation compared to TS in the caudate, accumbens, putamen, and thalamus. Subsequent analyses including clinical symptoms revealed that a larger pallidum and thalamus at baseline correlated with less improvement of tic symptoms at follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002190_sec4\" sec-type=\"conclusions\"><jats:title>Conclusion<\/jats:title><jats:p>These observations constitute some of the first prognostic biomarkers for tic disorders and suggest that these subregional shape and volume differences may be associated with the outcome of tic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1092852924002190","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T07:00:20Z","timestamp":1732777220000},"page":"652-664","source":"Crossref","is-referenced-by-count":4,"title":["Correlating clinical course with baseline subcortical shape in provisional tic 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