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The analysis aimed to determine if changes in objective or subjective cognitive function mediated the relationship between depression symptom severity and workplace outcomes. Cognitive function was measured by the Perceived Deficits Questionnaire (PDQ-5), the Digit Symbol Substitution Test (DSST), and the Trail Making Test Part B (TMT-B). Depression symptom severity was measured by the Montgomery\u2013\u00c5sberg Depression Rating Scale (MADRS). Workplace function was measured by the Sheehan Disability Scale (SDS) work\u2013school item.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002293_sec3\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>When co-varying for BMI, age, and sex, the association between MADRS and SDS work scores was partially mediated by PDQ-5 total scores and DSST total scores, but not DSST error scores and TMT-B time.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002293_sec4\"><jats:title>Limitations<\/jats:title><jats:p>This study was insufficiently powered to perform sub-group analyses to identify distinctions between MDD and BD populations as well as between antidepressant agents.<\/jats:p><\/jats:sec><jats:sec id=\"S1092852924002293_sec5\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that cognitive impairment in adults with MDD and BD is a critical mediator of workplace function and reinforces its importance as a therapeutic 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