{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:16:48Z","timestamp":1790299008766,"version":"4.1.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"unspecified","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1092852926100911_sec1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Schizophrenia frequently coexists with various physical and psychiatric comorbidities, but the influence of these comorbidities on mortality outcomes, particularly suicide mortality, among young patients with schizophrenia remains inadequately understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926100911_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We followed 109\u00a0900 young patients with schizophrenia aged 10\u201344\u00a0years for up to 10\u00a0years. We assessed 12 physical diseases, including diabetes, myocardial infarction, chronic liver disease, and malignancies, and two psychiatric disorders, namely alcohol use disorder and substance use disorder (SUD). Time-dependent Cox regression models were used to analyze the associations of these comorbidities with all-cause and suicide mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926100911_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SUD was strongly associated with increased all-cause mortality (hazard ratio [HR]: 1.80) and suicide mortality (HR: 3.76). Malignancies (HR: 14.39) and chronic kidney disease (HR: 6.46) were also strongly linked to all-cause mortality. The risk of all-cause mortality increased with the number of comorbidities (HR: \u22652: 2.02 versus 1: 1.45). No significant association was found between physical comorbidities and suicide risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926100911_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SUD is a significant risk factor for suicide mortality among young patients with schizophrenia. Physical comorbidities such as malignancies and chronic kidney disease are primarily associated with increased all-cause mortality in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1092852926100911","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:17:19Z","timestamp":1775535439000},"source":"Crossref","is-referenced-by-count":1,"title":["Physical and psychiatric comorbidities and their influence on all-cause and suicide mortality: a longitudinal study of 109,\u00a0900 young patients with schizophrenia"],"prefix":"10.1017","volume":"31","author":[{"given":"Shun-Chieh","family":"Yu","sequence":"first","affiliation":[{"name":"Ministry of Health and Welfare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"Taipei Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzeng-Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"National Yang Ming Chiao Tung University"},{"name":"Taipei Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6516-1073","authenticated-orcid":false,"given":"Mu-Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Taipei Veterans General Hospital"},{"name":"Taipei Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,7]]},"container-title":["CNS Spectrums"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1092852926100911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:01:36Z","timestamp":1785322896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1092852926100911\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026]]}},"alternative-id":["S1092852926100911"],"URL":"https:\/\/doi.org\/10.1017\/s1092852926100911","relation":{},"ISSN":["1092-8529","2165-6509"],"issn-type":[{"value":"1092-8529","type":"print"},{"value":"2165-6509","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e24"}}