{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:54:20Z","timestamp":1792065260189,"version":"4.4.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"unspecified","delay-in-days":287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Spectr."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1092852926101205_sec1\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Treatment-resistant depression (TRD) is a debilitating condition occurring in major depressive disorder (MDD) and bipolar II disorder (BP-II). Intermittent theta burst stimulation (iTBS) is an established neuromodulation approach for TRD, but standard delivery requires once-daily sessions over several weeks. Accelerated iTBS (aiTBS) may reduce treatment burden by temporally compressing delivery. We evaluated the implementation, tolerability, and clinical outcomes associated with a 5-day aiTBS schedule for adults experiencing TRD in MDD and BP-II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926101205_sec2\" sec-type=\"methods\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single-center, open-label, uncontrolled, prospective naturalistic cohort study, adults with MDD or BP-II experiencing TRD received 30 iTBS sessions (600 pulses\/session; total 18\u00a0000 pulses) over 5 days with 50-minute inter-session intervals. HAMD-17 was assessed at baseline, post-treatment, and 2-month follow-up. Secondary outcomes included Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), baseline Clinical Global Impression-Severity (CGI-S), post-treatment\/follow-up CGI-I, response\/remission rates, and adverse events. Longitudinal changes were evaluated using linear mixed-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926101205_sec3\" sec-type=\"results\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty-six participants contributed longitudinal data (mean age 44.3\u00a0years; 54.4% male). HAMD-17 response rates were 28.3% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a013) post-treatment and 37.0% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a017) at follow-up; remission rates were 26.1% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a012) and 32.6% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015), respectively. Improvements were also observed on PHQ-9 and GAD-7. On CGI-I, 52.2% were rated improved post-treatment and 60.9% at follow-up. The most common adverse event was transient, non-serious stimulation-site pain.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1092852926101205_sec4\" sec-type=\"conclusions\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The 5-day aiTBS schedule was logistically feasible, well-tolerated, and associated with reductions in depressive and anxiety symptom scores in a real-world TRD cohort. Randomized sham-controlled trials are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1092852926101205","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:12:43Z","timestamp":1792062763000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes following five-day accelerated intermittent theta burst stimulation for treatment-resistant depression in routine clinical practice: A prospective naturalistic cohort study"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5348-1213","authenticated-orcid":false,"given":"Asmi","family":"Khanna","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"},{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Espiritu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Zhu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervin","family":"Blair","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/051gsh239","id-type":"ROR","asserted-by":"publisher"}],"name":"Lawson Health Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Giovannetti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Abate","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice","family":"Knight","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Deutsch","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Waxman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"},{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amer M.","family":"Burhan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mcqge53","id-type":"ROR","asserted-by":"publisher"}],"name":"Ontario Shores Centre for Mental Health Sciences"},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,10,15]]},"reference":[{"key":"S1092852926101205_r30","doi-asserted-by":"publisher","DOI":"10.1177\/10398562241229623"},{"key":"S1092852926101205_r28","doi-asserted-by":"publisher","DOI":"10.1176\/appi.pn.2022.10.10.40"},{"key":"S1092852926101205_r10","first-page":"13","article-title":"The expanding evidence base for rTMS treatment of depression","volume":"26","author":"George","year":"2013","journal-title":"The Expanding Evidence Base for rTMS Treat of Depression: Curr Opin in Psychiatry"},{"key":"S1092852926101205_r6","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2014.16.1\/rduman"},{"key":"S1092852926101205_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nsa.2022.101014"},{"key":"S1092852926101205_r4","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2020-1627"},{"key":"S1092852926101205_r15","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41386-023-01599-z","article-title":"Accelerated TMS - 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