{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T21:22:23Z","timestamp":1700515343253},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":16467,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1969,7]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The distribution of G6PD-D in the Ferrara country has been studied by means of the Brilliant Cresyl Blue discoloration test: 2437 males have been tested in 11 localities.<\/jats:p><jats:p>The highest gene frequency of G6PD-D observed is consistent with the one expected after 25-30 generations of malaria selection, assuming an increased fitness of the heterozygotes, as it has been shown in computer simulated evolutionary trends for sex-linked genes. The thalassemia trait has also been shown to be very frequent in the same localities; its frequency is correlated with G6PD-D gene frequency and with the incidence of malaria in the past (1900).<\/jats:p><jats:p>G6PD-D frequency is not significantly correlated with malaria. Such a result is due to the significantly lower gene frequency of G6PD-D observed in the localities where the percentage of population affected by malaria was higher (40-60%). On the other hand, G6PD-D is frequently significantly correlated with malaria in the remaining localities where the incidence of the latter ranged from 0 to 35% of the affected population.<\/jats:p><jats:p>The mechanisms possibly involved in the determination of this distribution of G6PD-D are discussed.<\/jats:p>","DOI":"10.1017\/s1120962300011902","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T05:50:49Z","timestamp":1469598649000},"page":"271-284","source":"Crossref","is-referenced-by-count":5,"title":["Erythrocytary Glucose-6-Phosphate Dehydrogenase Deficiency \u2013 Study on its distribution in the province of Ferrara and its relation to malaria and thalassemia"],"prefix":"10.1017","volume":"18","author":[{"given":"E.","family":"Gandini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Menini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"De Filippis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Dell'Acqua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300011902_ref011","first-page":"187","article-title":"Sulle origini della microcitemia in Italia e nelle altre regioni della terra","volume":"2","author":"Silvestroni","year":"1952","journal-title":"Medicina"},{"key":"S1120962300011902_ref013","volume-title":"De Genetica Medica","volume":"IV","author":"Silvestroni","year":"1963"},{"key":"S1120962300011902_ref005","volume-title":"Abnormal Haemoglobins in Africa","author":"Motulsky","year":"1965"},{"key":"S1120962300011902_ref014","first-page":"378","article-title":"Population genetics of haemoglobin variants, thalassemia and glucose-6-phosphate dehydrogenase deficiency, with particular reference to the malaria hypothesis","volume":"34","author":"Siniscalco","year":"1966","journal-title":"Bull. W.H.O."},{"key":"S1120962300011902_ref004","first-page":"435","article-title":"Aspects of the population dynamics of the abnormal hemoglobin and glucose-6-phosphate dehydrogenase deficiency genes","volume":"16","author":"Livingstone","year":"1964","journal-title":"Amer. J. Hum. Genet."},{"key":"S1120962300011902_ref008","article-title":"Ricerche sul Popolamento della Pianura Ferrarese","volume":"III","author":"Ortolani","year":"1950","journal-title":"Bollettino Societ\u00e0 Geografica Italiana"},{"key":"S1120962300011902_ref015","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.57.3.835"},{"key":"S1120962300011902_ref006","volume-title":"Lo stato attuale della malaria in provincia di Ferrara","author":"Orta","year":"1917"},{"key":"S1120962300011902_ref003","first-page":"465","article-title":"Computer simulation of evolutionary trends in an X-linked trait. Application to glucose-6-phosphate dehydrogenase deficiency in man","volume":"17","author":"Lisker","year":"1967","journal-title":"Acta Genet. (Basel)"},{"key":"S1120962300011902_ref009","doi-asserted-by":"crossref","unstructured":"Pontremoli S. , Bargellesi A. , Conconi F. (1969). Globin synthesis in the Ferrara thalassemia population. Ann. N.Y. Acad. Sci. (In press).","DOI":"10.1111\/j.1749-6632.1969.tb27796.x"},{"key":"S1120962300011902_ref010","volume-title":"Progress in Medical Genetics","author":"Rucknagel","year":"1961"},{"key":"S1120962300011902_ref002","volume-title":"Abnormal Haemoglobins in Africa","author":"Allison","year":"1965"},{"key":"S1120962300011902_ref012","first-page":"51","volume-title":"J. J. M. S.: Atti delle Giornate di Studio sul Problema Sociale della Microcitemia e del Morbo di Cooley","author":"Silvestroni","year":"1961"},{"key":"S1120962300011902_ref007","article-title":"La Pianura Ferrarese","volume":"XV","author":"Ortolani","year":"1956","journal-title":"Memorie di Geografia Economica"},{"key":"S1120962300011902_ref001","volume-title":"Atti XV Congr. Geografico Italiano","author":"Alfieri","year":"1950"}],"container-title":["Acta geneticae medicae et gemellologiae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1120962300011902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T16:05:55Z","timestamp":1559405155000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1120962300011902\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,7]]}},"alternative-id":["S1120962300011902"],"URL":"https:\/\/doi.org\/10.1017\/s1120962300011902","relation":{},"ISSN":["1120-9623","2059-6316"],"issn-type":[{"value":"1120-9623","type":"print"},{"value":"2059-6316","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,7]]}}}