{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:25:41Z","timestamp":1756995941497},"reference-count":6,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":16923,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1968,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A multiple birth frequency of 5.59% has been found in 25 Klinefelter sibships, which is statistically significantly higher than expected (P &lt; 0.001).<\/jats:p><jats:p>A family investigation of a patient with Klinefelter's syndrome, who is a triplet himself, revealed 5 twin births and 2 triplet births in three generations.<\/jats:p><jats:p>The mortality of the 19 children from the 9 multiple births born in the 25 Klinefelter sibships was 53% up to the age of 3. Such a high mortality indicates that some of the twins and triplet births might have suffered from chromosome disorders contributing to the high mortality.<\/jats:p><jats:p>If the comparatively high frequency of twins in the sibships with Klinefelter's syndrome as well as Turner's syndrome is confirmed by further studies, this will indicate a relation between the cause of sex chromosome non-disjunction and multiple births or between the predisposition to non-disjunction and multiple births.<\/jats:p>","DOI":"10.1017\/s1120962300012798","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T09:49:12Z","timestamp":1469612952000},"page":"385-388","source":"Crossref","is-referenced-by-count":9,"title":["Twins and Klinefelter's Syndrome"],"prefix":"10.1017","volume":"17","author":[{"given":"Johannes","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300012798_ref001","first-page":"215","volume-title":"Ann. Hum. Gen.","volume":"25","author":"Boyer","year":"1961"},{"key":"S1120962300012798_ref004","first-page":"380","article-title":"Turner's syndrome, twinning, and an unusual variant of glucose-6-phosphate dehydrogenase","volume":"16","author":"Nance","year":"1964","journal-title":"Amer. J. Hum. Genet."},{"key":"S1120962300012798_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.3.2.114"},{"key":"S1120962300012798_ref003","volume-title":"The Nature and Origin of X Chromosome Aberrations in Turner's Syndrome","author":"Lindsten","year":"1963"},{"key":"S1120962300012798_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1963.tb00774.x"},{"key":"S1120962300012798_ref002","volume-title":"Twin Births and Twins from a Hereditary Point of View","author":"Dahlberg","year":"1926"}],"container-title":["Acta geneticae medicae et gemellologiae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1120962300012798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T19:16:29Z","timestamp":1559502989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1120962300012798\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,4]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,4]]}},"alternative-id":["S1120962300012798"],"URL":"https:\/\/doi.org\/10.1017\/s1120962300012798","relation":{},"ISSN":["1120-9623","2059-6316"],"issn-type":[{"value":"1120-9623","type":"print"},{"value":"2059-6316","type":"electronic"}],"subject":[],"published":{"date-parts":[[1968,4]]}}}