{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T11:55:28Z","timestamp":1721822128907},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":18932,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1962,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The incidence of pterygium was studied in an isolated highly inbred fisher population. A clinical and hematological examination was performed and the blood chemistry was studied. Genealogical tables (pedigrees) were prepared for all probands and the degree of consanguinity in their parents stated. Of the total of 479 subjects studied by random sampling, 19 (4 per cent) had pterygium with a relatively high manifestation age. No linkage was detected between the genes for the blood group systems, serum groups etc. and the gene for pterygium. Increased capillary fragility was established in 10 probands. Capillary permeability was studied in 2 probands by the concentration in the anterior chamber of intravenously administrated fluorescein, and the test was found to be weakly pathological in one of them. The serum cholesterol level was elevated in 5 of the patients studied. Ophthalmological examination indicated the accumulation of degenerative eye diseases. Pingueculum showed a more pronounced development in 10 of the 17 subjects examined than in the rest of the population. The possibility of recessive transmission of the hereditary predisposition is discussed with reference to the high frequency of inbreeding and the accumulation of pterygium within the isolated population. According to the special frequency-raising peristasis conditions in an outer archipelago community and to the mendelian segregation rate, a not sex-linked, simple dominant gene, with low penetrance and no selective disadvantage for the pterygium seems to be the most plausible explanation. Because of the late manifestation age, pterygium was observed only in 2 generations. The expressiveness of the gene was unsteady and asymmetry of pterygium in the eyes of the probands is not uncommon.<\/jats:p>","DOI":"10.1017\/s1120962300017844","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T09:45:42Z","timestamp":1469612742000},"page":"397-406","source":"Crossref","is-referenced-by-count":2,"title":["Pterygium in an Isolated Population"],"prefix":"10.1017","volume":"11","author":[{"given":"Henrik","family":"Forsius","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldur","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300017844_ref026","first-page":"35","article-title":"Dominante Vererbung des Flugelfells","volume":"99","author":"Strebel","year":"1937","journal-title":"Klin. Monatsbl. Augenh."},{"key":"S1120962300017844_ref027","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87295-2"},{"key":"S1120962300017844_ref022","first-page":"2","article-title":"Oftalmologiska iaktagelser hos ett arktiskt folk","volume":"53","author":"Norman-Hansen","year":"1911","journal-title":"Finska l\u00e6k.-saellsk. handl."},{"key":"S1120962300017844_ref006","first-page":"195","article-title":"A statistical contribution to the study of the \u00e6tiology of pterygium","volume":"2","author":"Diponegro","year":"1936","journal-title":"Folia ophth. orient."},{"key":"S1120962300017844_ref011","first-page":"448","article-title":"The problem of pterygium, with a survey of 53 cases. Vojno- sanit","volume":"13","author":"Fulgosi","year":"1956","journal-title":"Pregel"},{"key":"S1120962300017844_ref014","first-page":"419","article-title":"H\u00e9r\u00e9dit\u00e9 du pt\u00e9rigium","volume":"15","author":"Gutierrez-Ponce","year":"1893","journal-title":"Rec. opht., Par."},{"key":"S1120962300017844_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/BF02981562"},{"key":"S1120962300017844_ref010","doi-asserted-by":"publisher","DOI":"10.1159\/000301488"},{"key":"S1120962300017844_ref016","first-page":"152","article-title":"Lipid studies in pterygia, keratitis, and cataracts","volume":"18","author":"Holt","year":"1957","journal-title":"North Carolina M. J."},{"key":"S1120962300017844_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(44)92334-2"},{"key":"S1120962300017844_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300019053"},{"key":"S1120962300017844_ref003","first-page":"263","article-title":"Pterygia, etiologic theories, methods of treatment, and results","volume":"74","author":"Bartlett","year":"1951","journal-title":"California Med."},{"key":"S1120962300017844_ref029","first-page":"115","article-title":"Studien an eineiigen Zwillingen","volume":"101","author":"Weitz","year":"1924","journal-title":"Ztschr. klin. Med."},{"key":"S1120962300017844_ref007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1951.tb05854.x"},{"key":"S1120962300017844_ref002","first-page":"1640","article-title":"Acta XVII conc. ophth.","volume":"3","author":"Ascher","year":"1954","journal-title":"Canada - U.S.A."},{"key":"S1120962300017844_ref015","unstructured":"Hilgers J. A. Ch. : Pterygium on the island of Aruba. Thesis. Amsterdam, 1959."},{"key":"S1120962300017844_ref023","first-page":"207","article-title":"Pt\u00e9rygion et trachome","volume":"10","author":"S\u00e9dan","year":"1933","journal-title":"Rev. internat. trach."},{"key":"S1120962300017844_ref004","first-page":"1642","volume":"3","author":"Block","year":"1954","journal-title":"Acta XVII conc. ophth. Canada - U.S.A."},{"key":"S1120962300017844_ref024","first-page":"529","article-title":"Ojensygdomme i Gronland","volume":"111","author":"Skeller","year":"1949","journal-title":"Ugeskr. laeger."},{"key":"S1120962300017844_ref025","first-page":"1641","volume":"3","author":"Srinivasan","year":"1954","journal-title":"Acta XVI I cone, ophth., Canada - U.S.A."},{"key":"S1120962300017844_ref020","first-page":"339","article-title":"Pterygium among fishermen and farmers. A statistical and histopathologic study","volume":"8","author":"Li","year":"1958","journal-title":"Chin. J. Ophth."},{"key":"S1120962300017844_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(51)91034-3"},{"key":"S1120962300017844_ref018","first-page":"110","article-title":"A pterygium survey of the far north coast of New South Wales","volume":"16","author":"Kerkenezow","year":"1956","journal-title":"Tr. ophth. Soc. Australia"},{"key":"S1120962300017844_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(54)90294-9"},{"key":"S1120962300017844_ref028","first-page":"475","article-title":"Das Senium bei eineiigen und zweieiigen Zwillingen. Die Entstehung bisher exogen und durch Abnutzung erkl\u00e6rter Altersleiden","volume":"14","author":"Vogt","year":"1939","journal-title":"Arch. Julius Klaus-Stiftg. Vererb. forsch."},{"key":"S1120962300017844_ref009","unstructured":"Forsius H. & Eriksson A. W. : Unpublished data."},{"key":"S1120962300017844_ref019","first-page":"276","volume-title":"Cited by P. J. Waardenburg: Affections of the conjunctiva palpebrae et bulbi, in: Genetics and Ophthalmology","author":"Komai","year":"1947"},{"key":"S1120962300017844_ref008","volume-title":"Acta ophth.","author":"Forsius","year":"1954"},{"key":"S1120962300017844_ref001","first-page":"429","article-title":"Curieux cas de pt\u00e9rygion familial h\u00e9r\u00e9ditaire","volume":"20","author":"Armaignac","year":"1914","journal-title":"Clin, opth., Par."}],"container-title":["Acta geneticae medicae et gemellologiae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1120962300017844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T19:46:13Z","timestamp":1559677573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1120962300017844\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1962,10]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1962,10]]}},"alternative-id":["S1120962300017844"],"URL":"https:\/\/doi.org\/10.1017\/s1120962300017844","relation":{},"ISSN":["1120-9623","2059-6316"],"issn-type":[{"value":"1120-9623","type":"print"},{"value":"2059-6316","type":"electronic"}],"subject":[],"published":{"date-parts":[[1962,10]]}}}