{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T05:18:09Z","timestamp":1698038289063},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1-2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":16193,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1970,4]]},"abstract":"<jats:p>Uchida and Rowe (1957), Lamy et al (1957), as well as Campbell (1961), were of the opinion that genetic factors do not play an important role in the genesis of congenital heart deformities. These authors could not find any concordantly affected pair among a total of 32 MZ twin pairs. Impressive family case reports and systematic investigations (Fuhrmann, 1970; J\u00f6rgensen, 1970) do not support this assumption. The results of twin investigations by Nora et al (1967) also contradict previous results. Among a total of 37 twin pairs these authors found 6\/13 MZ and 1\/24 DZ concordantly affected pairs.<\/jats:p><jats:p>Our own investigations began in autumn, 1966 and were recently completed. With the help of the registrar of birth offices and the cardiological team of the University of G\u00f6ttingen (Prof. Dr. A. J. Beuren, Prof. Dr. H.-E. Hoffmeister, Prof. Dr. J. Koncz, Prof. Dr. J. Stoermer), we were able to find 50 index patients, each being a member of a twin pair, among 2427 propositi with different congenital heart defects.<\/jats:p><jats:p>Our own results are shown in Tab. I: 4\/21 MZ (19.0 \u00b1 8.6%) and 1\/24 DZ (4.2 \u00b1 4.1%) are concordantly affected. In five cases, the zygosity of the twins, as well as the diagnosis of respective cotwins, (stillborn or perinatal-dead) is unknown.<\/jats:p>","DOI":"10.1017\/s1120962300025610","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T09:51:06Z","timestamp":1469613066000},"page":"251-256","source":"Crossref","is-referenced-by-count":8,"title":["Twin Studies in Congenital Heart Diseases"],"prefix":"10.1017","volume":"19","author":[{"given":"G.","family":"J\u00f6rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300025610_ref016","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.1.1.2"},{"key":"S1120962300025610_ref005","unstructured":"Fuhrmann W. (1970). Fehlbildungen des Herzens und der gro\u03b2en Gef\u00e4\u03b2e. In Becker P. E. : Handbuch der Humangenetik."},{"key":"S1120962300025610_ref015","first-page":"133","article-title":"Discordant heart anomalies in twins","volume":"9","author":"Uchida","year":"1957","journal-title":"Amer. J. Hum. Genet."},{"key":"S1120962300025610_ref007","first-page":"111","article-title":"The patent ductus","volume":"25","author":"Holman","year":"1953","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"S1120962300025610_ref002","first-page":"445","article-title":"Twins and congenital heart disease","volume":"10","author":"Campbell","year":"1961","journal-title":"Acta Genet. (Basel)"},{"key":"S1120962300025610_ref013","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.20.3.327"},{"key":"S1120962300025610_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S1120962300025452"},{"key":"S1120962300025610_ref012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196709142771104"},{"key":"S1120962300025610_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1968.tb00052.x"},{"key":"S1120962300025610_ref006","volume-title":"Una serie non selezionata di cardiopatie congenite in gemelli","author":"Gedda","year":"1961"},{"key":"S1120962300025610_ref014","first-page":"139","article-title":"Beitrag zur \u00c4tiologie der angeborenen Herzmi\u03b2bildungen auf Grund von Zwillingsuntersuchungen","volume":"100","author":"Steinlein","year":"1952","journal-title":"Mschr. Kinderheilk."},{"key":"S1120962300025610_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(52)90177-3"},{"key":"S1120962300025610_ref001","first-page":"52","volume-title":"Birth Defects Original Article Series","volume":"1","author":"Benirschke","year":"1965"},{"key":"S1120962300025610_ref008","unstructured":"J\u00f6rgensen G. (1970). Fehlbildungen des Herzens und der gro\u03b2en Gef\u00e4\u03b2e. II. In Becker P. E. : Handbuch der Humangenetik (In press)."},{"key":"S1120962300025610_ref004","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.34.3.503"},{"key":"S1120962300025610_ref010","first-page":"17","article-title":"Genetic and non-genetic factors in the etiology of congenital heart disease: a study of 1188 cases","volume":"9","author":"Lamy","year":"1957","journal-title":"Amer. J. Hum. Genet."}],"container-title":["Acta geneticae medicae et gemellologiae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1120962300025610","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T19:21:51Z","timestamp":1559416911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1120962300025610\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,4]]},"references-count":16,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1970,4]]}},"alternative-id":["S1120962300025610"],"URL":"https:\/\/doi.org\/10.1017\/s1120962300025610","relation":{},"ISSN":["1120-9623","2059-6316"],"issn-type":[{"value":"1120-9623","type":"print"},{"value":"2059-6316","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,4]]}}}