{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T23:40:33Z","timestamp":1656891633090},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":17379,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Selected subjects have been treated with cyclophosphamide and nitrogen mustard. The granulocytopenia has been followed by repeated<jats:italic>in vivo<\/jats:italic>labeling with DFP<jats:sup>32<\/jats:sup>and the endotoxin test for evaluating the availability of the granulocyte reserve. The effect of steroid treatment on the recovery of the granulopoiesis has been studied with autotransfusions of<jats:italic>in vitro<\/jats:italic>DFP<jats:sup>32<\/jats:sup>labeled granulocytes in the same subject and performed before, during and after the treatment was discontinued.<\/jats:p><jats:p>The following conclusions have been reached:<\/jats:p><jats:p>1. The efficiency of the granulopoiesis is based upon the availability of the bone marrow granulocyte reserve.<\/jats:p><jats:p>2. The bone marrow granulocyte mobilization with endotoxin and the<jats:italic>in vivo<\/jats:italic>granulocyte labeling with DFP<jats:sup>32<\/jats:sup>give an evaluable information about the bone marrow granulocyte reserve.<\/jats:p><jats:p>3. The granulocytopenia due to antiblastic therapy corresponds to a depletion of the bone marrow granulocyte reserve.<\/jats:p><jats:p>4. The recovery of a \u201cnormal granulocyte count\u201d preceeds the rebuilt of a \u201cnormal availability\u201d of the bone marrow granulocyte reserve.<\/jats:p><jats:p>5. The recovery of the blood granulocyte count after prednison is not associated with any favourable change of the granulopoiesis.<\/jats:p>","DOI":"10.1017\/s1120962300026251","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T09:49:05Z","timestamp":1469612945000},"page":"18-29","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Granulopoiesis during Antiblastic Treatment"],"prefix":"10.1017","volume":"17","author":[{"given":"A.","family":"Fieschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sacchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300026251_ref008","doi-asserted-by":"publisher","DOI":"10.1159\/000209624"},{"key":"S1120962300026251_ref017","first-page":"60","article-title":"Osservazioni sulla dinamica dei granulociti nelle neutropenie","volume":"9","author":"Sacchetti","year":"1964","journal-title":"Rie. Emoter. ImmunoematoL"},{"key":"S1120962300026251_ref015","volume-title":"La granulocitopoiesi: fisiopatologia e clinica","author":"Sacchetti","year":"1963"},{"key":"S1120962300026251_ref004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105177"},{"key":"S1120962300026251_ref016","first-page":"324","article-title":"La riserva midollare di granulociti neutrofi\u00eci","volume":"8","author":"Sacchetti","year":"1964","journal-title":"Minerva Nucleare"},{"key":"S1120962300026251_ref006","volume-title":"Dinamica dei Granulociti: Leucocitosi e Leucopenie","author":"Fieschi","year":"1961"},{"key":"S1120962300026251_ref012","first-page":"287","volume-title":"Atti XVII Congr. Naz. Soc. It. Ematol.","author":"Sacchetti","year":"1960"},{"key":"S1120962300026251_ref005","first-page":"245","volume-title":"H. Ford. Hosp. Int. 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Invest"},{"key":"S1120962300026251_ref011","first-page":"333","article-title":"Studio della leucocitosi prodotta dalla somministrazione endovena di endotossine batteriche nell'uomo: provenienza, distribuzione e durata nel sangue dei granulociti mobilizzati","volume":"8","author":"Ponassi","year":"1964","journal-title":"Minerva Nucleare"},{"key":"S1120962300026251_ref014","first-page":"730","article-title":"Effetto del trattamento prednisonico sul rinnovamento dei granulociti nel sangue e sulla granulopoiesi in condizioni normali e patologiche","volume":"15","author":"Sacchetti","year":"1962","journal-title":"Folia Endocrin."},{"key":"S1120962300026251_ref001","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1182\/blood.V14.4.303.303","article-title":"Leukokinetic studies. I -A method for labeling leukocytes with diisopropylfluorophosphate (DFP32)","volume":"14","author":"Athens","year":"1959","journal-title":"Blood"},{"key":"S1120962300026251_ref007","doi-asserted-by":"publisher","DOI":"10.1159\/000205762"},{"key":"S1120962300026251_ref013","first-page":"1142","article-title":"I granulociti nel sangue: massa totale e compartimenti","volume":"37","author":"Sacchetti","year":"1962","journal-title":"Boll. Soc. It. Biol. Sper."},{"key":"S1120962300026251_ref009","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104167"},{"key":"S1120962300026251_ref019","first-page":"55","article-title":"Neutrophilic leukocyte reserve of the bone marrow: \u00abin vivo\u00bb detection and quantitation with DFP32","volume":"9","author":"Sacchetti","year":"1965","journal-title":"Minerva Nucleare"}],"container-title":["Acta geneticae medicae et gemellologiae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1120962300026251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T23:01:04Z","timestamp":1656889264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1120962300026251\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1968,1]]}},"alternative-id":["S1120962300026251"],"URL":"https:\/\/doi.org\/10.1017\/s1120962300026251","relation":{},"ISSN":["1120-9623","2059-6316"],"issn-type":[{"value":"1120-9623","type":"print"},{"value":"2059-6316","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,1]]}}}