{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:16:11Z","timestamp":1699701371197},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"unspecified","delay-in-days":22858,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta genet. med. gemellol."],"published-print":{"date-parts":[[1952,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Thalassemia, that I propose to call Microkarterocytosis, can be divided into three forms to be distinguished under the names of minima (healthy carriers), minor (Rietti and Greppi's disease), major (Cooley disease).<\/jats:p><jats:p>It can be inferred that Thalassemia is a mutation developped in a mediterranean superior paleolitic race that showed also the character high cheek bones.<\/jats:p><jats:p>In my researches of 1941-42 I for first showed that thalassemia is a dominant hereditary character with homozigotic letal effect (heterozigotes the healthy carriers, homozigotes Cooley' patients).<\/jats:p><jats:p>Heterozigotes throug an increased expression of the morbid gene develop Rietti and Greppi disease, as I inferred in 1949.<\/jats:p><jats:p>The researches on genetics that I carried later on Drepanocytosis have shown a behaviour equal yo that observed in Thalassemia.<\/jats:p><jats:p>In Drepanocytosis the heterozigote condition determines the healty carriers and the less serious cases of sickle cell anemia, the condition of homozigote the most serious form of this anemia.<\/jats:p><jats:p>A morbid form clinically similiar to the slight cases of Cooley disease is detectable in subjects whose parents show separately one the Thalassemia-stigmata and the other the Drepanocytosis-stigmata. For this latter form the name of Thalassodrepanocytosis is suggested.<\/jats:p><jats:p>The presence of drepanocytosis inindividuals of european races can be explained with very ancient crosses with individuals of negro races.<\/jats:p>","DOI":"10.1017\/s1120962300027219","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T09:41:05Z","timestamp":1469612465000},"page":"19-30","source":"Crossref","is-referenced-by-count":3,"title":["Thalassemia (Microkarterocytosis) and Drepanocytosis their Forms and Genetics"],"prefix":"10.1017","volume":"2","author":[{"given":"Ignazio","family":"Gatto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,8,1]]},"reference":[{"key":"S1120962300027219_ref058","volume-title":"Clinical Ematology","author":"Wintrobe","year":"1942"},{"key":"S1120962300027219_ref046","first-page":"657","article-title":"Sulla eritropatia familiare tipo Herrick","volume":"20","author":"Pontoni","year":"1939","journal-title":"Haematologia"},{"key":"S1120962300027219_ref040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1182\/blood.V6.5.389.389","article-title":"The inheritance of the Sickling Phenomenon, with particular reference to Sickle cell. 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