{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:14:44Z","timestamp":1744287284596},"reference-count":93,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T00:00:00Z","timestamp":1318291200000},"content-version":"unspecified","delay-in-days":4149,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epidemiol Psichiatr Soc"],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:title>RIASSUNTO<\/jats:title><jats:p><jats:bold>Scopo<\/jats:bold>\u2013 In questa rassegna sono stati raccolti ed analizzati i dati conoscitivi provenienti da ricerche che si occupano della relazione tra depressione e malattia di Alzheimer (<jats:italic>Alzheimer's Disease<\/jats:italic>, AD).<jats:bold>Metodo<\/jats:bold>\u2013 E' stata analizzata in modo sistematico la letteratura, attingendo sia alle segnalazione presenti nella banca-dati<jats:italic>Medline<\/jats:italic>che alle informazioni ricavabili da una analisi ragionata degli studi pubblicati.<jats:bold>Risultati<\/jats:bold>\u2013 La prevalenza di segni e sintomi depressivi nei pazienti con AD \u00e8 piuttosto elevata (40-50%). II ruolo della depressione all'interno dell'AD (indipendente, prodromo, fattore di rischio) deve in realt\u00e0 essere ancora definito. I dati sulla familiarit\u00e0 per la depressione suggeriscono che l'AD agisca come stimolo scatenante la depressione su una base di vulnerabilit\u00e0 genetica. Su un versante biologico l'insorgenza di depressione nell'AD potrebbe derivare da uno sbilanciamento tra sistema colinergico e noradrenergico, mentre sul versante della comprensione psicologica la depressione costituirebbe una reazione di lutto per il decadimento cognitivo. Gli attuali strumenti diagnostici validati in pazienti con AD costituiscono un buon ausilio nella clinica e nella ricerca. L'individuazione di una depressione nel corso di un AD rimane in realt\u00e0 sempre difficoltosa se non sono presenti sintomi affettivi franchi, poich\u00e8 i sintomi cognitivi, psicomotori e vegetativi appartengono sia alia depressione che all'AD. I disturbi affettivi pi\u00f9 frequentemente riportati sono la depressione maggiore e la distimia. Nel trattamento farmacologico si suggerisce l'utilizzo dei farmaci antidepressivi con minori effetti anticolinergici. Buoni risultati sono stati ottenuti anche adattando diversi tipi di psicoterapia alle particolari esigenze del paziente demente.<jats:bold>Conclusioni<\/jats:bold>\u2013 L'attuale dibattito scientifico si basa su conoscenze ancora limitate e parcellizzate. La futura ricerca in questo campo dovr\u00e0 produrre studi che siano in grado di soddisfare criteri di indagine pi\u00f9 rigidi, con una migliore definizione dei casi, una stratificazione per fattori di rischio ed una prospettiva longitudinale.<\/jats:p>","DOI":"10.1017\/s1121189x00008319","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T15:19:24Z","timestamp":1318346364000},"page":"126-139","source":"Crossref","is-referenced-by-count":2,"title":["Expressions of depression in Alzheimer's disease. 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