{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T18:41:43Z","timestamp":1726425703761},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T00:00:00Z","timestamp":1235606400000},"content-version":"unspecified","delay-in-days":4623,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the dorsal midbrain has been implicated in cognitive processes in animals, its role in humans is unclear. We report the neuropsychological and postmortem neuropathological findings of a 52-yr-old university professor who developed a profound dementia in association with a focal dorsal midbrain lesion. The patient's disorder appeared to result from a tuberculous granuloma based on the clinical course and autopsy results. Neuropsychologically, he exhibited a generalized impairment across most of the cognitive domains assessed. His deficits were not explained by impaired arousal, specific sensory or motor defects, depression, or hydrocephalus. Although there are inherent limitations to a single-case investigation, our observations are consistent with animal studies that have demonstrated that focal dorsal midbrain lesions may result in cognitive impairment. We propose that the dorsal midbrain is involved in cognitive processing via modulation of thalamocortical networks. (<jats:italic>JINS<\/jats:italic>, 1996, 2, 359\u2013367.)<\/jats:p>","DOI":"10.1017\/s1355617700001387","type":"journal-article","created":{"date-parts":[[2009,2,26]],"date-time":"2009-02-26T08:54:01Z","timestamp":1235638441000},"page":"359-367","source":"Crossref","is-referenced-by-count":12,"title":["Dementia associated with dorsal midbrain lesion"],"prefix":"10.1017","volume":"2","author":[{"given":"K.J.","family":"Meador","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.W.","family":"Loring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.D.","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Yaghmai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.D.","family":"Styren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.T.","family":"DeKosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,2,26]]},"reference":[{"key":"S1355617700001387_ref049","doi-asserted-by":"publisher","DOI":"10.1159\/000102854"},{"volume-title":"Wechsler Intelligence Scale for Children-Revised (W1SC-R)","year":"1974","author":"Wechsler","key":"S1355617700001387_ref047"},{"key":"S1355617700001387_ref046","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/80.4.510"},{"key":"S1355617700001387_ref045","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1988.00520290025008"},{"key":"S1355617700001387_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90270-E"},{"key":"S1355617700001387_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(87)80011-8"},{"key":"S1355617700001387_ref041","doi-asserted-by":"publisher","DOI":"10.1002\/dev.420180606"},{"key":"S1355617700001387_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90397-5"},{"key":"S1355617700001387_ref038","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3758\/BF03337819","article-title":"Puzzle-box learning impairments in young rats with lesions to the \u201cgeneral learning system","volume":"17","author":"Thompson","year":"1987","journal-title":"Psychobiology"},{"key":"S1355617700001387_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90006-1"},{"key":"S1355617700001387_ref035","doi-asserted-by":"publisher","DOI":"10.1126\/science.8235588"},{"key":"S1355617700001387_ref034","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-08-02541.1990"},{"key":"S1355617700001387_ref028","first-page":"7","volume-title":"Proceedings of the First International Congress of Neurological Sciences","author":"Penfield","year":"1959"},{"key":"S1355617700001387_ref027","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/81.2.231"},{"key":"S1355617700001387_ref026","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/77.1.1"},{"key":"S1355617700001387_ref024","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.30.1.0014"},{"key":"S1355617700001387_ref023","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1970.00990040435006"},{"key":"S1355617700001387_ref021","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(92)90012-4"},{"volume-title":"The waking brain","year":"1962","author":"Magoun","key":"S1355617700001387_ref019"},{"key":"S1355617700001387_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(91)90038-T"},{"key":"S1355617700001387_ref018","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/5.1.1"},{"key":"S1355617700001387_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90158-K"},{"key":"S1355617700001387_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90986-6"},{"key":"S1355617700001387_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90333-Y"},{"key":"S1355617700001387_ref032","first-page":"577","article-title":"Demonstration of a reciprocal connection between the periaqueductal gray matter and the reticular nucleus of the thalamus","volume":"181","author":"Rinvik","year":"1990","journal-title":"Anatomical Embryology"},{"volume-title":"Contributions to neuropsychological assessment","year":"1983","author":"Benton","key":"S1355617700001387_ref004"},{"key":"S1355617700001387_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/0926-6410(93)90015-W"},{"key":"S1355617700001387_ref022","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902140206"},{"volume-title":"Principles of human physiology","year":"1853","author":"Carpenter","key":"S1355617700001387_ref006"},{"key":"S1355617700001387_ref020","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1983.49.3.567"},{"key":"S1355617700001387_ref008","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.6.682"},{"key":"S1355617700001387_ref013","first-page":"1371","article-title":"Wilder Penfield: His legacy to neurology","volume":"116","author":"Jasper","year":"1977","journal-title":"Canadian Medical Association Journal"},{"volume-title":"The diagnosis of stupor and coma","year":"1982","author":"Plum","key":"S1355617700001387_ref030"},{"key":"S1355617700001387_ref039","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3758\/BF03337818","article-title":"Inhibitory deficits in rats rendered \u201cmentally retarded\u201d by early brain damage","volume":"17","author":"Thompson","year":"1989","journal-title":"Psychobiology"},{"key":"S1355617700001387_ref014","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1987.00520230017007"},{"key":"S1355617700001387_ref037","first-page":"197","volume-title":"Brain mechanisms. Papers in memory of Robert Thompson","author":"Thompson","year":"1993"},{"key":"S1355617700001387_ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1536"},{"key":"S1355617700001387_ref025","first-page":"513","article-title":"Epileptic automatism and the centrencephalic integrating system","volume":"30","author":"Penfield","year":"1952","journal-title":"Research Publication Association for Research in Nervous Mental Disease"},{"key":"S1355617700001387_ref042","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(86)90016-3"},{"key":"S1355617700001387_ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.8.1493"},{"key":"S1355617700001387_ref012","doi-asserted-by":"publisher","DOI":"10.1080\/01688638508401258"},{"key":"S1355617700001387_ref016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.35.4.568"},{"volume-title":"Neuropsychological assessment","year":"1995","author":"Lezak","key":"S1355617700001387_ref017"},{"volume-title":"Neurological anatomy in relation to clinical medicine","year":"1981","author":"Brodal","key":"S1355617700001387_ref005"},{"volume-title":"Manual for the Wechsler Adult Intelligence Scale-Revised","year":"1981","author":"Wechsler","key":"S1355617700001387_ref048"},{"volume-title":"Multilingual aphasia examination","year":"1978","author":"Benton","key":"S1355617700001387_ref003"},{"key":"S1355617700001387_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(90)90079-N"},{"key":"S1355617700001387_ref010","doi-asserted-by":"publisher","DOI":"10.1126\/science.7268442"},{"key":"S1355617700001387_ref015","doi-asserted-by":"publisher","DOI":"10.1126\/science.8052851"}],"container-title":["Journal of the International Neuropsychological Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1355617700001387","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T23:06:49Z","timestamp":1710112009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1355617700001387\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["S1355617700001387"],"URL":"https:\/\/doi.org\/10.1017\/s1355617700001387","relation":{},"ISSN":["1355-6177","1469-7661"],"issn-type":[{"type":"print","value":"1355-6177"},{"type":"electronic","value":"1469-7661"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}