{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:11:44Z","timestamp":1790784704173,"version":"4.1.0"},"reference-count":68,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T00:00:00Z","timestamp":1076025600000},"content-version":"unspecified","delay-in-days":36,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>\n                    Hypoxia damages multiple organ systems especially those with high \noxygen utilization such as the central nervous system. The purpose of \nthis study was to compare the neuropathological and neuropsychological \neffects of hypoxia in patients with either carbon monoxide poisoning or \nobstructive sleep apnea. Neuroimaging revealed evidence of hippocampal \natrophy in both groups although a linear relationship between \nhippocampal volume and memory performance was found only for selected \ntests and only in the sleep apnea group. There were significant \ncorrelations between hippocampal volume and performance on measures \nrelated to nonverbal\/information processing. Generalized brain \natrophy, as measured by the ventricle-to-brain ratio, was more common \nin the carbon monoxide poisoning group compared to the obstructive \nsleep apnea group. Performance on tests of executive function improved \nfollowing treatment with nasal continuous positive airway pressure \ntreatment in the obstructive sleep apnea group but there was no \nassociated improvement in general intellectual function. We found that \nhypoxia due to obstructive sleep apnea and CO poisoning resulted in \nneuropathological changes and neuropsychological impairments. The \nobserved group differences provide insight into the relationship \nbetween etiology of injury, neuropathological changes, and clinical \npresentation. (\n                    <jats:italic>JINS<\/jats:italic>\n                    , 2004,\n                    <jats:italic>10<\/jats:italic>\n                    , 60\u201371.)\n                  <\/jats:p>","DOI":"10.1017\/s1355617704101082","type":"journal-article","created":{"date-parts":[[2004,1,29]],"date-time":"2004-01-29T12:14:37Z","timestamp":1075378477000},"page":"60-71","source":"Crossref","is-referenced-by-count":138,"title":["Effects of hypoxia on the brain: Neuroimaging and \nneuropsychological findings following carbon monoxide poisoning and \nobstructive sleep apnea"],"prefix":"10.1017","volume":"10","author":[{"given":"SHAWN D.","family":"GALE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAMONA O.","family":"HOPKINS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,2,6]]},"reference":[{"key":"S1355617704101082_ref053","doi-asserted-by":"crossref","unstructured":"Reynolds, C.R. , Hopkins, R.O. , & Bigler, E.D. 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