{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:35:21Z","timestamp":1791210921691,"version":"4.1.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:p>We examined the possible role of autonomic activity in \nHuntington's disease (HD) during a risky decision making task. \nSkin conductance responses (SCRs) of 15 HD participants and 16 healthy \ncontrols were measured while they performed a computerized version of \nthe Simulated Gambling Task (SGT). The results replicated our previous \nfinding of a performance decrement in HD, and showed that HD was \nassociated with an altered pattern of SCRs during the risky decision \ntask. Specifically, the healthy controls produced increased SCRs \nfollowing selections from the disadvantageous decks and following \nlosing selections. In contrast, the SCRs of the HD group did not \ndifferentiate between wins and losses. These findings indicate a \nreduced impact of loss on decision-making processes under risky \nconditions in HD. (<jats:italic>JINS<\/jats:italic>, 2004, <jats:italic>10<\/jats:italic>, \n239\u2013245.)<\/jats:p>","DOI":"10.1017\/s1355617704102105","type":"journal-article","created":{"date-parts":[[2004,3,10]],"date-time":"2004-03-10T20:35:06Z","timestamp":1078950906000},"page":"239-245","source":"Crossref","is-referenced-by-count":44,"title":["Reduced autonomic responsiveness to gambling task losses in \nHuntington's disease"],"prefix":"10.1017","volume":"10","author":[{"given":"MEGHAN C.","family":"CAMPBELL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JULIE C.","family":"STOUT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PETER R.","family":"FINN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"S1355617704102105_ref023","doi-asserted-by":"crossref","unstructured":"Marder, K. , Zhao, H. , Myers, R.H. , Cudkowicz, M. , Kayson, E. , Kieburtz, K. , Orme, C. , Paulsen, J. , Penney, J.B. , Siemers, E. , Shoulson, I. , and the Huntington Study Group (2000).Rate of functional decline in Huntington's disease.Neurology,54(2),452\u2013458.","DOI":"10.1212\/WNL.54.2.452"},{"key":"S1355617704102105_ref008","unstructured":"Bechara, A. , Tranel, D. , & Damasio, A.R. (2000).Poor judgement in spite of high intellect: Neurological evidencefor emotional intelligence. In R. Bar-On (Ed.),The handbook of emotional intelligence: Theory, development,assessment, and application at home, school, and in the workplace (pp.192\u2013214).San Francisco:Jossey-Bass."},{"key":"S1355617704102105_ref028","doi-asserted-by":"crossref","unstructured":"Tomb, I. , Hauser, M. , Deldin, P. , & Caramazza, A. (2002).Do somatic markers mediate decisions on the gambling task.Nature Neuroscience,5,1103\u20131104.","DOI":"10.1038\/nn1102-1103"},{"key":"S1355617704102105_ref014","unstructured":"Damasio, A.R. (1994).Descartes' error: Emotion, reason, and the human brain.New York:Avon Books, Inc."},{"key":"S1355617704102105_ref022","doi-asserted-by":"crossref","unstructured":"Lawson, E.A. (1981).Skin conductance responses in Huntington's chorea progeny.Psychophysiology,18,32\u201334.","DOI":"10.1111\/j.1469-8986.1981.tb01537.x"},{"key":"S1355617704102105_ref005","doi-asserted-by":"crossref","unstructured":"Bechara, A. , Damasio, H. , Tranel, D. , & Anderson, S.W. (1998).Dissociation of working memory from decision making within thehuman prefrontal cortex.Journal of Neuroscience,18,428\u2013437.","DOI":"10.1523\/JNEUROSCI.18-01-00428.1998"},{"key":"S1355617704102105_ref001","doi-asserted-by":"crossref","unstructured":"Alexander, G.E. , DeLong, M.R. , & Strick, P.L. (1986).Parallel organization of functionally segregated circuits linkingbasal ganglia and cortex.Annual Review of Neuroscience,9,357\u2013381.","DOI":"10.1146\/annurev.ne.09.030186.002041"},{"key":"S1355617704102105_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0010-0277(94)90018-3"},{"key":"S1355617704102105_ref019","doi-asserted-by":"publisher","DOI":"10.1007\/BF02734048"},{"key":"S1355617704102105_ref020","doi-asserted-by":"crossref","unstructured":"Hare, R.D. & Blevings, G. (1975).Defensive responses to phobic stimuli.Biological Psychology,3,1\u201313.","DOI":"10.1016\/0301-0511(75)90002-2"},{"key":"S1355617704102105_ref029","unstructured":"Tranel, D. , Bechara, A. , & Damasio, A.R. (2000).Decision making and the somatic marker hypothesis. In M.S. Gazzaniga (Ed.),The new cognitive neurosciences(2nd ed., pp.1047\u20131061).Cambridge, MA:MIT Press."},{"key":"S1355617704102105_ref030","doi-asserted-by":"crossref","unstructured":"Verfaellie, M. , Bauer, R.M. , & Bowers, D. (1991).Autonomic and behavioral evidence of implicit memory in amnesia.Brain and Cognition,15,10\u201325.","DOI":"10.1016\/0278-2626(91)90012-W"},{"key":"S1355617704102105_ref006","doi-asserted-by":"crossref","unstructured":"Bechara, A. , Damasio, H. , Tranel, D. , & Damasio, A.R. (1997).Deciding advantageously before knowing the advantageous strategy.Science,275,1293\u20131295.","DOI":"10.1126\/science.275.5304.1293"},{"key":"S1355617704102105_ref027","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617701711095"},{"key":"S1355617704102105_ref017","doi-asserted-by":"crossref","unstructured":"Esteves, F. , Parra, C. , Dimberg, U. , & Ohman, A. 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Adams (Eds.),Neuropsychological assessment of neuropsychiatric disorders (pp.312\u2013341).New York:Oxford University Press."},{"key":"S1355617704102105_ref024","unstructured":"Mattis, S. (1988).Dementia Rating Scale: Professional manual.Odessa, FL:Psychological Assessment Resources, Inc."},{"key":"S1355617704102105_ref016","doi-asserted-by":"crossref","unstructured":"Dawson, M.E. , Filion, D.L. , & Schell, A.M. (1989).Is elicitation of the autonomic orienting response associated withallocation of processing resources? Psychophysiology,26,560\u2013572.","DOI":"10.1111\/j.1469-8986.1989.tb00710.x"},{"key":"S1355617704102105_ref003","doi-asserted-by":"crossref","unstructured":"Bechara, A. , Damasio, H. , Damasio, A.R. , & Lee, G.P. 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(1987).Electrodermal activity in patients with Huntington's diseaseand their progeny.Psychophysiology,24,522\u2013527.","DOI":"10.1111\/j.1469-8986.1987.tb00330.x"}],"container-title":["Journal of the International Neuropsychological Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1355617704102105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T21:22:40Z","timestamp":1554499360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1355617704102105\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S1355617704102105"],"URL":"https:\/\/doi.org\/10.1017\/s1355617704102105","relation":{},"ISSN":["1355-6177","1469-7661"],"issn-type":[{"value":"1355-6177","type":"print"},{"value":"1469-7661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}