{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:05:32Z","timestamp":1790755532917,"version":"4.1.0"},"reference-count":55,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2005,5,4]],"date-time":"2005-05-04T00:00:00Z","timestamp":1115164800000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:p>Human exposure to naturally occurring marine toxins has been associated with a range of neurobehavioral abnormalities. The toxins are produced by harmful algal blooms (HABs) and are typically contracted through seafood consumption. The primary target of many of the HAB toxins is the neurologic system, and the neurobehavioral symptoms associated with the HAB illnesses have influenced public health policy. The HAB-related illnesses most frequently linked to neuropsychological disturbance are Amnesic Shellfish Poisoning, Ciguatera Fish Poisoning, and Possible Estuarine Associated Syndrome, which is associated with exposure to the<jats:italic>Pfiesteria piscicida<\/jats:italic>organism. Although the neurophysiologic mechanisms underlying many of the HAB illnesses have been well delineated, the literature examining the neuropsychological impairments is unclear and needs to be defined. This review is intended to introduce an emerging area of study linking HAB illnesses with neuropsychological changes. 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(1988).Successful treatment of ciguatera fish poisoning with intravenousmannitol.Journal of the American Medical Association,259,2740\u20132742.","DOI":"10.1001\/jama.1988.03720180066035"},{"key":"S1355617705050381_ref023","unstructured":"Grattan, L.M. , Oldach, D. , Tracy, J.K. , & Greenberg, D.R. (1998).Neurobehavioral complaints of symptomatic persons exposed toPfiesteria piscicida or morphologically related organisms.Maryland Medical Journal,47,127\u2013129."},{"key":"S1355617705050381_ref012","doi-asserted-by":"crossref","unstructured":"Dunn, J.T. , Lees-Haley, P.R. , Brown, R.S. , Williams, C.W. , & English, L.T. (1995).Neurotoxic complaint base rates of personal injury claimants:Implications for neuropsychological assessment.Journal of Clinical Psychology,51,577\u2013584.","DOI":"10.1002\/1097-4679(199507)51:4<577::AID-JCLP2270510418>3.0.CO;2-E"},{"key":"S1355617705050381_ref042","unstructured":"Simpson, T.W. (1998).A citizens guide to the Water Quality Improvement Act of1998.Maryland Cooperative Extension, University of Maryland,College Park, Eastern Shore."},{"key":"S1355617705050381_ref004","unstructured":"Bagnis, R. (1992).Public health, epidemiological and socioeconomic patterns ofCiguatera in Tahiti (pp.157\u2013168). InProceedings of the Third International Conference on CiguateraFish Poisoning, April 30\u2013May 5, 1990, La Parguera, PuertoRico.Quebec:Polyscience Publications."},{"key":"S1355617705050381_ref051","unstructured":"United States Environmental Protection Agency ,Integrated Risk Information System (IRIS): Toluene (CASRN108-88-2)(1992).http:\/\/www.epa.gov\/iris\/subst\/0118.htm,http:\/\/cfpub.epa.gov\/iris\/quickview.cvm?substance_nmbr=0118"},{"key":"S1355617705050381_ref048","doi-asserted-by":"crossref","unstructured":"Tryphonas, L. & Iverson, F. (1990).Neuropathology of excitatory neurotoxins: the domoic acidmodel.Toxicologic Pathology,18 (1, Pt 2),165\u2013169","DOI":"10.1177\/019262339001800122"},{"key":"S1355617705050381_ref001","doi-asserted-by":"crossref","unstructured":"Arena, P. , Levin, B. , Fleming, L.E. , Friedman, M.A. , & Blythe, D.G. (2004).A pilot study of the cognitive and psychological correlates ofchronic ciguatera poisoning.Harmful Algae,3,51\u201360.","DOI":"10.1016\/j.hal.2003.08.006"},{"key":"S1355617705050381_ref027","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.111-a18"},{"key":"S1355617705050381_ref016","unstructured":"Fleming, L.E. , Katz, D. , Bean, J.A. , & Hammond, R. (2001a).Epidemiology of seafood poisoning. In Y.H. Hui , D. Kitts , & P.S. Stanfield (Eds.),Foodborne disease handbook,2nd Edition.New York:Marcel Dekker, Inc."},{"key":"S1355617705050381_ref006","unstructured":"Barker, R. (1997).And the waters turned to blood.New York:Simon & Shuster."},{"key":"S1355617705050381_ref047","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006213222505"},{"key":"S1355617705050381_ref002","unstructured":"Backer, L.C. , Dickey, R. , Poli, M. , Davis, C. , Luber, G. , Friedman, M. , Fleming, L.E. , Patel, M. , & Blythe, D. (2004).Development of a biological marker for exposure to ciguateratoxins.A poster presented at the 11th International Conference onHarmful Algae Blooms, Cape Town, South Africa."},{"key":"S1355617705050381_ref041","unstructured":"Shoemaker, R.C. & Hudnell, H.K. (2001).Possible estuary-associated syndrome: Symptoms, vision andtreatment.Environmental Health Perspectives,109,539\u2013545."},{"key":"S1355617705050381_ref038","unstructured":"Samet, J. , Bignami, G.S. , Feldman, R. , Hawkins, W. , Neff, J. , & Smayda, T. (2001).Pfiesteria: Review of the science and identification of researchgaps. Report for the National Center for Environmental Health, Centers forDisease Control and Prevention.Environmental Health Perspectives,109,639\u2013659."},{"key":"S1355617705050381_ref020","doi-asserted-by":"publisher","DOI":"10.1080\/15287399509532051"},{"key":"S1355617705050381_ref055","unstructured":"White, R.F. , Feldman, R.G. , & Proctor, S.P. (2000).Neurotoxicology. In B.S. Fogel , R.B. Schiffer , & S.M. Rao (Eds.),Synopsis of neuropsychiatry, (pp.503\u2013510).Philadelphia, Pennsylvania:Lippincott Williams & Wilkins."},{"key":"S1355617705050381_ref032","unstructured":"Lipton, D.W. 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(1979).Clinical observation on 3009 cases of ciguatera (fish poisoning) inthe South Pacific.American Tropical Medical Hygiene,28,1067\u20131073.","DOI":"10.4269\/ajtmh.1979.28.1067"},{"key":"S1355617705050381_ref046","unstructured":"Swinker, M. , Koltai, D. , Wilkins, J. , & Woodhall, S. (2001b).Is there an estuary-associated syndrome in North Carolina? Findingsin a series of hotline callers.North Carolina Medical Journal,62,126\u2013132."},{"key":"S1355617705050381_ref024","unstructured":"Greenberg, D.R. , Tracy, J.K. , & Grattan, L.M. (1998).A critical review of the Pfiesteria hysteria hypothesis.Maryland Medical Journal,47,133\u2013136."},{"key":"S1355617705050381_ref017","unstructured":"Fleming, L.E. , Katz, D. , Bean, J.A. , & Hammond, R. (2001b).Epidemiology of Seafood Poisoning. In Y.H. Hui and D.D. 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ThePractitioner's Handbook, (pp.1\u201351).Amsterdam, The Netherlands:Elsevier Science Publishers B.V."},{"key":"S1355617705050381_ref015","doi-asserted-by":"publisher","DOI":"10.1177\/019262339902700511"},{"key":"S1355617705050381_ref045","doi-asserted-by":"crossref","unstructured":"Swinker, M. , Koltai, D. , Wilkins, J. , Hudnell, K. , Hall, C. , Darcey, D. , Robertson, K. , Schmechel, D. , Stopford, W. , & Music, S. (2001a).Estuary-associated syndrome in North Carolina: An occupationalprevalence study.Environmental Health Perspectives,109,21\u201326.","DOI":"10.1289\/ehp.0110921"},{"key":"S1355617705050381_ref039","unstructured":"Schmechel, D.E. & Koltai, D.C. (2001).Potential human health effects associated with laboratory exposuresto Pfiesteria piscicida.Environmental Health Perspectives,109,775\u2013779."},{"key":"S1355617705050381_ref029","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4679(199711)53:7<699::AID-JCLP7>3.0.CO;2-D"},{"key":"S1355617705050381_ref028","doi-asserted-by":"crossref","unstructured":"Lees-Haley, P.R. (2000).Methodology in epidemiological studies of human neurobehavioraltoxicity: A case study with critical review.Psychological Reports,86,85\u2013101.","DOI":"10.2466\/pr0.2000.86.1.85"},{"key":"S1355617705050381_ref014","unstructured":"Fleming, L.E. , Bean, J.A. , & Baden, D.G. (1995).Epidemiology of toxic marine phytoplankta. In G.M. Hallegraeff , D. Anderson , & A.D. Cembella (Eds.),UNESCO IOC manual on harmful marine phytoplankta (33) (pp.475\u2013488).Paris, France:UNESCO."},{"key":"S1355617705050381_ref019","doi-asserted-by":"crossref","unstructured":"Gillespie, N.C. , Lewis, R.J. , Pearn, J.H. , Bourke, A.T. , Holmes, M.J. , Bourke, J.B. , & Shields, W.J. (1986).Ciguatera in Australia: Occurrence, clinical features,pathophysiology and management.The Medical Journal of Australia,145,584\u2013589.","DOI":"10.5694\/j.1326-5377.1986.tb139504.x"},{"key":"S1355617705050381_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)02132-1"},{"key":"S1355617705050381_ref018","doi-asserted-by":"crossref","unstructured":"Foo, S.J. , Jeyatnam, J. , & Koh, D. (1990).Chronic neurobehavioural effects of toluene.British Journal of Industrial Medicine,47,480\u2013484.","DOI":"10.1136\/oem.47.7.480"},{"key":"S1355617705050381_ref049","doi-asserted-by":"crossref","unstructured":"Tryphonas, L. , Truelove, J. , & Iverson, F. 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(1995).Ciguatera fish poisoning: A Southern California epidemic.The Western Journal of Medicine,163,31\u201336."},{"key":"S1355617705050381_ref011","unstructured":"Centers for Disease Control and Prevention (March 2004).About Harmful Algal Blooms. CDC Harmful Algal Blooms.Department of Health and Human Services.www.cdc.gov\/hab\/factsheet.pdf."},{"key":"S1355617705050381_ref050","doi-asserted-by":"crossref","unstructured":"Tryphonas, L. , Truelove, J. , Nera, E. , & Iverson, F. (1990b).Acute neurotoxicity of domoic acid in the rat.Toxicologic Pathology,18 (1, Pt 1),1\u20139.","DOI":"10.1177\/019262339001800101"},{"key":"S1355617705050381_ref031","unstructured":"Lewis, R.J. & King, G.K. (1996).Ciguatera (Fish Poisoning). In J.A. Williamson , P.J. Fenner , J.W. Burnett , & J.F. 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