{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T21:55:21Z","timestamp":1770760521704,"version":"3.50.0"},"reference-count":75,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T00:00:00Z","timestamp":1125014400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>Treatment for childhood acute lymphoblastic leukemia (ALL), which \nincludes CNS prophylaxis, is associated with central and peripheral \nneurotoxicity. The purpose of the present study was to analyze the effects \nof chemotherapy on various levels of visuomotor control in survivors of \nchildhood ALL treated without cranial irradiation, and to identify risk \nfactors for possible deficits. Visuomotor function was compared between \nchildren after treatment for ALL (<jats:italic>n<\/jats:italic> = 34), children after \ntreatment for Wilms tumor, which consists of non-CNS directed chemotherapy \n(<jats:italic>n<\/jats:italic> = 38), and healthy controls (<jats:italic>n<\/jats:italic> = 151). Three tasks \nwere administered: a simple visual reaction time task and two tasks \nmeasuring visuomotor control with one requiring a higher level of \ncognitive control than the other. Visuomotor deficits were detected only \nin the ALL group, with poorer performance restricted to the condition \nrequiring the highest level of control. Significant risk factors for \npoorer performance were female gender and a short time since end of \ntreatment, and a trend was found for a young age at diagnosis. A high \ncumulative methotrexate dose was an adverse predictive factor in girls. \nThe results indicate that chemotherapy-induced central neurotoxicity in \nchildhood ALL treatment is associated with higher order visuomotor control \ndeficits. Girls appear to be particularly vulnerable. (<jats:italic>JINS<\/jats:italic>, \n2005, <jats:italic>11<\/jats:italic>, 554\u2013565.)<\/jats:p>","DOI":"10.1017\/s1355617705050666","type":"journal-article","created":{"date-parts":[[2005,10,7]],"date-time":"2005-10-07T17:38:21Z","timestamp":1128706701000},"page":"554-565","source":"Crossref","is-referenced-by-count":54,"title":["Visuomotor control in survivors of childhood acute lymphoblastic \nleukemia treated with chemotherapy only"],"prefix":"10.1017","volume":"11","author":[{"given":"ANNEMIEKE I.","family":"BUIZER","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LEO M.J.","family":"DE SONNEVILLE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARRY M.","family":"VAN DEN HEUVEL-EIBRINK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CHARLES","family":"NJIOKIKTJIEN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANJO J.P.","family":"VEERMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"S1355617705050666_ref033","doi-asserted-by":"crossref","unstructured":"Heitger, M.H. , Anderson, T.J. , Jones, R.D. , Dalrymple-Alford, J.C. , Frampton, C.M. , & Ardagh, M.W. 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