{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:14:17Z","timestamp":1790745257441,"version":"4.1.0"},"reference-count":56,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T00:00:00Z","timestamp":1174348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>Awareness of cognitive dysfunction shown by individuals with Mild \nCognitive Impairment (MCI), a condition conferring risk for \nAlzheimer's disease (AD), is variable. Anosognosia, or unawareness of \nloss of function, is beginning to be recognized as an important clinical \nsymptom of MCI. However, little is known about the brain substrates \nunderlying this symptom. We hypothesized that MCI participants' \nactivation of cortical midline structures (CMS) during self-appraisal \nwould covary with level of insight into cognitive difficulties (indexed by \na discrepancy score between patient and informant ratings of cognitive \ndecline in each MCI participant). To address this hypothesis, we first \ncompared 16 MCI participants and 16 age-matched controls, examining brain \nregions showing conjoint or differential BOLD response during \nself-appraisal. Second, we used regression to investigate the relationship \nbetween awareness of deficit in MCI and BOLD activity during \nself-appraisal, controlling for extent of memory impairment. Between-group \ncomparisons indicated that MCI participants show subtly attenuated CMS \nactivity during self-appraisal. Regression analysis revealed a highly \nsignificant relationship between BOLD response during self-appraisal and \nself-awareness of deficit in MCI. This finding highlights the level of \nanosognosia in MCI as an important predictor of response to self-appraisal \nin cortical midline structures, brain regions vulnerable to changes in \nearly AD. (<jats:italic>JINS<\/jats:italic>, 2007, <jats:italic>13<\/jats:italic>, 450\u2013461.)<\/jats:p>","DOI":"10.1017\/s1355617707070488","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T07:43:52Z","timestamp":1177055032000},"page":"450-461","source":"Crossref","is-referenced-by-count":93,"title":["Anosognosia in mild cognitive impairment: Relationship to activation \nof cortical midline structures involved in self-appraisal"],"prefix":"10.1017","volume":"13","author":[{"given":"MICHELE L.","family":"RIES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BRITTA M.","family":"JABBAR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TAYLOR W.","family":"SCHMITZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MEHUL A.","family":"TRIVEDI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CAREY E.","family":"GLEASON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CYNTHIA M.","family":"CARLSSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HOWARD A.","family":"ROWLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SANJAY","family":"ASTHANA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STERLING C.","family":"JOHNSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,20]]},"reference":[{"key":"S1355617707070488_ref016","doi-asserted-by":"crossref","unstructured":"Harwood, D.G. , Sultzer, D.L. , Feil, D. , Monserratt, L. , Freedman, E. , & Mandelkern, M.A. (2005).Frontal lobe hypometabolism and impaired insight in Alzheimerdisease.American Journal of Geriatric Psychiatry,13,934\u2013941.","DOI":"10.1097\/00019442-200511000-00003"},{"key":"S1355617707070488_ref023","doi-asserted-by":"crossref","unstructured":"Jezzard, P. & Balaban, R.S. 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