{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:12:36Z","timestamp":1791324756714,"version":"4.3.1"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,20]],"date-time":"2007-03-20T00:00:00Z","timestamp":1174348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:p>Huntington's disease (HD) is a neurodegenerative disorder \ndiagnosed clinically with the development of choreiform movements. \nHowever, neuropsychological studies have demonstrated cognitive and \npsychiatric changes during the preclinical phase (pre-HD) prior to formal \ndiagnosis. Previous studies have demonstrated the sensitivity of time \nreproduction tasks to basal ganglia pathology, as seen in clinical HD and \nParkinson's disease. In this study, 29 pre-HD participants, ranging \nfrom 3 to 39 years from estimated onset (YEO) of HD based on genetic \ntesting and chronological age, were administered the paced finger-tapping \ntask using target intervals of 600 and 1200 ms. Mean inter-response \ninterval, a measure of timing accuracy, did not systematically deviate \nfrom the target interval as a function of YEO. In contrast, timing \nvariability increased curvilinearly as a function of YEO, but not with \nchronological age alone. Motor timing variability, but not accuracy, may \nserve as a marker to define the earliest behavioral changes in HD. The \npresent study is among the first to examine the relationship between \nbehavioral measures and YEO in pre-HD. (<jats:italic>JINS<\/jats:italic>, 2007, <jats:italic>13<\/jats:italic>, \n539\u2013543.)<\/jats:p>","DOI":"10.1017\/s1355617707070671","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T07:43:52Z","timestamp":1177055032000},"page":"539-543","source":"Crossref","is-referenced-by-count":81,"title":["Motor timing variability increases in preclinical Huntington's \ndisease patients as estimated onset of motor symptoms approaches"],"prefix":"10.1017","volume":"13","author":[{"given":"SEAN C.","family":"HINTON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANE S.","family":"PAULSEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"RAYMOND G.","family":"HOFFMANN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NORMAN C.","family":"REYNOLDS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JANICE L.","family":"ZIMBELMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN M.","family":"RAO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,3,20]]},"reference":[{"key":"S1355617707070671_ref010","doi-asserted-by":"crossref","unstructured":"Langbehn, D.R. , Brinkman, R.R. , Falush, D. , Paulsen, J.S. , Hayden, M.R. , & International Huntington's Disease CollaborativeGroup .(2004).A new model for prediction of the age of onset and penetrance forHuntington's disease based on CAG length.Clinical Genetics,65,267\u2013277.","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"S1355617707070671_ref013","unstructured":"Paulsen, J.S. , Zimbelman, J.L. , Hinton, S.C. , Langbehn, D.R. , Leveroni, C.L. , Benjamin, M.L. , Reynolds, N.C. , & Rao, S.M. 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