{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:23:48Z","timestamp":1784179428172,"version":"3.55.0"},"reference-count":54,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T00:00:00Z","timestamp":1197590400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>The extent to which letter-by-letter reading results from a specific orthographic deficit, as compared with a nonspecific disturbance in basic visuoperceptual mechanisms, is unclear. The current study directly compared processing of letters and digits in a letter-by-letter reader, G.M., using a rapid serial visual presentation (RSVP) task and a speeded matching task. Comparisons were made to a group of six brain-damaged individuals without reading deficits. In the RSVP task, G.M. had increased difficulty reporting the target identities when they were letters, as compared with digits. Although this general pattern was also evident in the control group, the magnitude of the letter\u2013digit accuracy difference was greater in G.M. Similarly, in the matching task, G.M. was slower to match letters than digits, relative to the control group, although his response times to both item types were increased. These data suggest that letter-by-letter reading, at least in this case, results from a visuoperceptual encoding deficit that particularly affects letters, but also extends to processing of digits to a lesser extent. Results are consistent with the notion that a left occipitotemporal area is specialized for letter processing with greater bilaterality in the visual processing of digits. (<jats:italic>JINS<\/jats:italic>, 2008,<jats:italic>14<\/jats:italic>, 164\u2013173.)<\/jats:p>","DOI":"10.1017\/s1355617708080119","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T09:03:08Z","timestamp":1197622988000},"page":"164-173","source":"Crossref","is-referenced-by-count":14,"title":["A comparison of letter and digit processing in letter-by-letter reading"],"prefix":"10.1017","volume":"14","author":[{"given":"JANET L.","family":"INGLES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GAIL A.","family":"ESKES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,12,14]]},"reference":[{"key":"S1355617708080119_ref007","doi-asserted-by":"crossref","unstructured":"Behrmann, M. & Shallice, T. (1995).Pure alexia: A nonspatial visual disorder affecting letter activation.Cognitive Neuropsychology,12,409\u2013454.","DOI":"10.1080\/02643299508252004"},{"key":"S1355617708080119_ref016","doi-asserted-by":"crossref","unstructured":"Duncan, J. , Ward, R. , & Shapiro, K. (1994).Direct measurement of attentional dwell time in human vision.Nature,369,313\u2013315.","DOI":"10.1038\/369313a0"},{"key":"S1355617708080119_ref020","doi-asserted-by":"crossref","unstructured":"Friedman, R.B. & Alexander, M.P. (1984).Pictures, images, and pure alexia: A case study.Cognitive Neuropsychology,1,9\u201323.","DOI":"10.1080\/02643298408252014"},{"key":"S1355617708080119_ref037","doi-asserted-by":"crossref","unstructured":"Patterson, K. & Kay, J. (1982).Letter-by-letter reading: Psychological descriptions of a neurological syndrome.Quarterly Journal of Experimental Psychology. 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(1996).Differential sensitivity of human visual cortex to faces, letter strings, and textures: A functional magnetic resonance imaging study.Journal of Neuroscience,16,5205\u20135215.","DOI":"10.1523\/JNEUROSCI.16-16-05205.1996"},{"key":"S1355617708080119_ref049","doi-asserted-by":"crossref","unstructured":"Taylor, T.L. & Hamm, J. (1997).Category effects in temporal visual search.Canadian Journal of Experimental Psychology,51,36\u201346.","DOI":"10.1037\/1196-1961.51.1.36"},{"key":"S1355617708080119_ref032","doi-asserted-by":"crossref","unstructured":"Maki, W.S. , Bussard, G. , Lopez, K. , & Digby, B. (2003).Sources of interference in the attentional blink: Target-distractor similarity revisited.Perception and Psychophysics,65,188\u2013201.","DOI":"10.3758\/BF03194794"},{"key":"S1355617708080119_ref036","doi-asserted-by":"crossref","unstructured":"Mycroft, R.H. , Mitchell, D.C. , & Kay, J. (2002).An evaluation of statistical procedures for comparing an individual's performance with that of a group of controls.Cognitive Neuropsychology,19,291\u2013299.","DOI":"10.1080\/02643290143000150"},{"key":"S1355617708080119_ref054","unstructured":"Wilkinson, G.S. (1993).WRAT-3. The Wide Range Achievement Test.Wilmington:Wide Range, Inc."},{"key":"S1355617708080119_ref008","doi-asserted-by":"crossref","unstructured":"Bowers, J.S. , Arguin, M. , & Bub, D.N. (1996).Fast and specific access to orthographic knowledge in a case of letter-by-letter surface alexia.Cognitive Neuropsychology,13,525\u2013567.","DOI":"10.1080\/026432996381917"},{"key":"S1355617708080119_ref050","doi-asserted-by":"crossref","unstructured":"Teng, E.L. & Sperry, R.W. (1973).Interhemispheric interaction during simultaneous bilateral presentation of letters or digits in commissurotomized patients.Neuropsychologia,11,131\u2013140.","DOI":"10.1016\/0028-3932(73)90001-8"},{"key":"S1355617708080119_ref002","unstructured":"Arguin, M. & Bub, D.N. (1994).Functional mechanisms in pure alexia: Evidence from letter processing. In M.J. Farah & G. Ratcliff (Eds.),The neuropsychology of high-level vision (pp.149\u2013171).Hillsdale, NJ:Lawrence Erlbaum."},{"key":"S1355617708080119_ref030","unstructured":"Kucera, F. & Francis, W.N. (1967).Computational analysis of present-day American English.Providence, RI:Brown University Press."},{"key":"S1355617708080119_ref022","doi-asserted-by":"crossref","unstructured":"Gauthier, I. , Tarr, M.J. , Moylan, J. , Skudlarski, P. , Gore, J.C. , & Anderson, A.W. 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(1892).Contribution a l'etude anatomo-pathologique et clinique des differentes varietes de cecite-verbale.Memoires Societe Biologique,4,61\u201390."},{"key":"S1355617708080119_ref051","doi-asserted-by":"crossref","unstructured":"Ward, R. , Duncan, J. , & Shapiro, K. (1997).Effects of similarity, difficulty, and nontarget presentation on the time course of visual attention.Perception and Psychophysics,59,593\u2013600.","DOI":"10.3758\/BF03211867"},{"key":"S1355617708080119_ref001","doi-asserted-by":"crossref","unstructured":"Arguin, M. & Bub, D.N. (1993).Single-character processing in a case of pure alexia.Neuropsychologia,31,435\u2013458.","DOI":"10.1016\/0028-3932(93)90059-9"},{"key":"S1355617708080119_ref033","doi-asserted-by":"crossref","unstructured":"McLaughlin, E.N. , Shore, D.I. , & Klein, R.M. (2001).The attentional blink is immune to masking-induced data limits.The Quarterly Journal of Experimental Psychology. 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