{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:45:52Z","timestamp":1786999552727,"version":"build-2736575974"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The relative influence of amyloid burden, neuronal structure and function, and prior cognitive performance on prospective memory decline among asymptomatic late middle-aged individuals at risk for Alzheimer's disease (AD) is currently unknown. We investigated this using longitudinal cognitive data from 122 middle-aged adults (21 \u201cDecliners\u201d and 101 \u201cStables\u201d) enrolled in the Wisconsin Registry for Alzheimer's Prevention who underwent multimodality neuroimaging [\n                    <jats:sup>11<\/jats:sup>\n                    C-Pittsburgh Compound B (PiB),\n                    <jats:sup>18<\/jats:sup>\n                    F-fluorodeoxyglucose (FDG), and structural\/functional magnetic resonance imaging (fMRI)] 5.7 \u00b1 1.4 years (range = 2.9\u20138.9) after their baseline cognitive assessment. Covariate-adjusted regression analyses revealed that the only imaging measure that significantly distinguished Decliners from Stables (\n                    <jats:italic>p<\/jats:italic>\n                    = .027) was a Neuronal Function composite derived from FDG and fMRI. In contrast, several cognitive measures, especially those that tap episodic memory, significantly distinguished the groups (\n                    <jats:italic>p<\/jats:italic>\n                    's&lt;.05). Complementary receiver operating characteristic curve analyses identified the Brief Visuospatial Memory Test-Revised (BVMT-R) Total (.82 \u00b1 .05,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; .001), the BVMT-R Delayed Recall (.73 \u00b1 .06,\n                    <jats:italic>p<\/jats:italic>\n                    = .001), and the Reading subtest from the Wide-Range Achievement Test-III (.72 \u00b1 .06,\n                    <jats:italic>p<\/jats:italic>\n                    = .002) as the top three measures that best discriminated the groups. These findings suggest that early memory test performance might serve a more clinically pivotal role in forecasting future cognitive course than is currently presumed. (\n                    <jats:italic>JINS<\/jats:italic>\n                    , 2014,\n                    <jats:italic>20<\/jats:italic>\n                    , 1\u201312)\n                  <\/jats:p>","DOI":"10.1017\/s1355617714000113","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T10:00:16Z","timestamp":1394618416000},"page":"422-433","source":"Crossref","is-referenced-by-count":26,"title":["Amyloid Burden, Neuronal Function, and Cognitive Decline in Middle-Aged Adults at Risk for Alzheimer's Disease"],"prefix":"10.1017","volume":"20","author":[{"given":"Ozioma C.","family":"Okonkwo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Koscik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Jonaitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin A.","family":"Cleary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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