{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:21:10Z","timestamp":1782321670112,"version":"3.54.5"},"reference-count":64,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T00:00:00Z","timestamp":1422230400000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The current study sought to examine the utility of intra-individual variability (IIV) in distinguishing participants with prodromal Huntington disease (HD) from nongene-expanded controls. IIV across 15 neuropsychological tasks and within-task IIV using a self-paced timing task were compared as a single measure of processing speed (Symbol Digit Modalities Test [SDMT]) in 693 gene-expanded and 191 nongene-expanded participants from the PREDICT-HD study. After adjusting for depressive symptoms and motor functioning, individuals estimated to be closest to HD diagnosis displayed higher levels of across- and within-task variability when compared to controls and those prodromal HD participants far from disease onset (<jats:italic>F<\/jats:italic><jats:sub><jats:italic>ICV<\/jats:italic>(3,877)<\/jats:sub>=11.25;<jats:italic>p<\/jats:italic>&lt;.0001;<jats:italic>F<\/jats:italic><jats:sub><jats:italic>PacedTiming<\/jats:italic>(3,877)<\/jats:sub>=22.89;<jats:italic>p<\/jats:italic>&lt;.0001). When prodromal HD participants closest to HD diagnosis were compared to controls, Cohen\u2019s<jats:italic>d<\/jats:italic>effect sizes were larger in magnitude for the within-task variability measure, paced timing (\u22121.01), and the SDMT (\u22120.79) and paced tapping coefficient of variation (CV) (\u22120.79) compared to the measures of across-task variability [CV (0.55); intra-individual standard deviation (0.26)]. Across-task variability may be a sensitive marker of cognitive decline in individuals with prodromal HD approaching disease onset. However, individual neuropsychological tasks, including a measure of within-task variability, produced larger effect sizes than an index of across-task IIV in this sample. (<jats:italic>JINS<\/jats:italic>, 2015,<jats:italic>21<\/jats:italic>, 8\u201321)<\/jats:p>","DOI":"10.1017\/s1355617714001076","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T10:44:41Z","timestamp":1422269081000},"page":"8-21","source":"Crossref","is-referenced-by-count":10,"title":["Intra-individual Variability in Prodromal Huntington Disease and Its Relationship to Genetic Burden"],"prefix":"10.1017","volume":"21","author":[{"given":"Mandi","family":"Musso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly James","family":"Westervelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey 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