{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:52:11Z","timestamp":1775278331978,"version":"3.50.1"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T00:00:00Z","timestamp":1583366400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1355617720000181_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>The Apolipoprotein (APOE) \u03b54 allele increases the risk for mild cognitive impairment (MCI) and dementia, but not all carriers develop MCI\/dementia. The purpose of this exploratory study was to determine if early and subtle preclinical signs of cognitive dysfunction and medial temporal lobe atrophy are observed in cognitively intact \u03b54 carriers who subsequently develop MCI.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000181_as2\" sec-type=\"other\"><jats:title>Methods:<\/jats:title><jats:p>Twenty-nine healthy, cognitively intact \u03b54 carriers (\u03b53\/\u03b54 heterozygotes; ages 65\u201385) underwent neuropsychological testing and MRI-based measurements of medial temporal volumes over a 5-year follow-up interval; data were converted to<jats:italic>z<\/jats:italic>-scores based on a non-carrier group consisting of 17 \u03b53\/\u03b53 homozygotes.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000181_as3\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>At follow-up, 11 \u03b54 carriers (38%) converted to a diagnosis of MCI. At study entry, the MCI converters had significantly lower scores on the Mini-Mental State Examination, Rey Auditory Verbal Learning Test (RAVLT) Trials 1\u20135, and RAVLT Immediate Recall compared to non-converters. MCI converters also had smaller MRI volumes in the left subiculum than non-converters. Follow-up logistic regressions revealed that left subiculum volumes and RAVLT Trials 1\u20135 scores were significant predictors of MCI conversion.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000181_as4\" sec-type=\"other\"><jats:title>Conclusions:<\/jats:title><jats:p>Results from this exploratory study suggest that \u03b54 carriers who convert to MCI exhibit subtle cognitive and volumetric differences years prior to diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1355617720000181","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T09:05:23Z","timestamp":1583399123000},"page":"733-738","source":"Crossref","is-referenced-by-count":13,"title":["Episodic Memory and Hippocampal Volume Predict 5-Year Mild Cognitive Impairment Conversion in Healthy Apolipoprotein \u03b54 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