{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:39:50Z","timestamp":1777084790725,"version":"3.51.4"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1355617720000673_as1\"><jats:title>Objective:<\/jats:title><jats:p>Visual memory (ViM) declines early in Alzheimer\u2019s disease (AD). However, it is unclear whether ViM impairment is evident in the preclinical stage and relates to markers of AD pathology. We examined the relationship between ViM performance and<jats:italic>in vivo<\/jats:italic>markers of brain pathology in individuals with autosomal dominant AD (ADAD).<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000673_as2\"><jats:title>Methods:<\/jats:title><jats:p>Forty-five cognitively unimpaired individuals from a Colombian kindred with the Presenilin 1 (<jats:italic>PSEN1<\/jats:italic>) E280A ADAD mutation (19 carriers and 26 noncarriers) completed the Rey\u2013Osterrieth Complex Figure immediate recall test, a measure of ViM. Cortical amyloid burden and regional tau deposition in the entorhinal cortex (EC) and inferior temporal cortex (IT) were measured using<jats:sup>11<\/jats:sup>C-Pittsburgh compound B positron emission tomography (PET) and<jats:sup>11<\/jats:sup>F-flortaucipir PET, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000673_as3\"><jats:title>Results:<\/jats:title><jats:p>Cognitively unimpaired carriers and noncarriers did not differ on ViM performance. Compared to noncarriers, carriers had higher levels of cortical amyloid and regional tau in both the EC and IT. In cognitively unimpaired carriers, greater cortical amyloid burden, higher levels of regional tau, and greater age were associated with worse ViM performance. Only a moderate correlation between regional tau and ViM performance remained after adjusting for verbal memory scores. None of these correlations were observed in noncarriers.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617720000673_as5\"><jats:title>Conclusions:<\/jats:title><jats:p>Results suggest that AD pathology and greater age are associated with worse ViM performance in ADAD before the onset of clinical symptoms. Further investigation with larger samples and longitudinal follow-up is needed to examine the utility of ViM measures for identifying individuals at high risk of developing dementia later in life.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1355617720000673","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T04:34:51Z","timestamp":1596774891000},"page":"47-55","source":"Crossref","is-referenced-by-count":9,"title":["Association Between Visual Memory and<i>In Vivo<\/i>Amyloid and Tau Pathology in Preclinical Autosomal Dominant Alzheimer\u2019s Disease"],"prefix":"10.1017","volume":"27","author":[{"given":"Yamile","family":"Bocanegra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua 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