{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:05:08Z","timestamp":1793754308247,"version":"4.6.1"},"reference-count":46,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1355617722000509_as1\"><jats:title>Objective:<\/jats:title><jats:p>Cognitive impairment is one of the most common symptoms of anti-leucine rich glioma inactivated 1 (anti-LGI-1) encephalitis, but little is known about the cognitive profile of these patients. This study characterized the cognitive profile of patients with anti-LGI-1 encephalitis and compared patterns of impairment to healthy controls and other patient groups with known temporal lobe\/limbic involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617722000509_as2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective analysis of adult patients with anti-LGI-1 encephalitis who underwent neuropsychological assessment was conducted. Performance patterns of anti-LGI-1 patients were compared to patients deemed cognitively healthy (HC), as well as patients with amnestic mild cognitive impairment (aMCI) and temporal lobe epilepsy (TLE).<\/jats:p><\/jats:sec><jats:sec id=\"S1355617722000509_as3\"><jats:title>Results:<\/jats:title><jats:p>Among 10 anti-LGI encephalitis patients (60% male, median age 67.5 years) who underwent neuropsychological testing (median = 38.5 months from symptom onset), cognitive deficits were common, with 100% of patients showing impairment (\u22641.5 <jats:italic>SD<\/jats:italic> below mean) on 1+ measures and 80% on 2+ measures. Patients with anti-LGI-1 encephalitis performed worse than controls on measures of basic attention, vigilance, psychomotor speed, complex figure copy, and aspects of learning\/memory. Of measures which differed from controls, there were no differences between the anti-LGI-1 and TLE patients, while the anti-LGI-1 patients exhibited higher rates of impairment in basic attention and lower rates of delayed verbal memory impairment compared to the aMCI patients.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617722000509_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Long-term cognitive deficits are common in patients with anti-LGI-1 encephalitis and involve multiple domains. Future research in larger samples is needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1355617722000509","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T09:50:49Z","timestamp":1662371449000},"page":"541-550","source":"Crossref","is-referenced-by-count":29,"title":["Cognitive outcomes in anti-LGI-1 encephalitis"],"prefix":"10.1017","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2859-806X","authenticated-orcid":false,"given":"Rachel","family":"Galioto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Aboseif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamini","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3628-0334","authenticated-orcid":false,"given":"John","family":"Lace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Kunchok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"S1355617722000509_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.10.005"},{"key":"S1355617722000509_ref33","volume-title":"Symbol digit modalities test (SDMT). 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