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Baseline global cognition was a z-score composite of five factor scores from a comprehensive neuropsychological battery. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale. Cardiovascular health was operationalized through systolic blood pressure. A mediation model controlling for sociodemographics, childhood health, and childhood socioeconomic status estimated indirect effects of ACEs on global cognition via depressive symptoms and blood pressure. Racial differences were probed via t-tests and stratified models.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617723000474_as3\"><jats:title>Results:<\/jats:title><jats:p>A negative indirect effect of ACEs on cognition was observed through depressive symptoms [<jats:italic>\u03b2<\/jats:italic> = \u2212.040, 95% CI (\u2212.067, \u2212.017)], but not blood pressure, for the whole sample. Black participants reported more ACEs (Cohen\u2019s <jats:italic>d<\/jats:italic> = .21), reported more depressive symptoms (Cohen\u2019s <jats:italic>d<\/jats:italic> = .35), higher blood pressure (Cohen\u2019s <jats:italic>d<\/jats:italic> = .41), and lower cognitive scores (Cohen\u2019s <jats:italic>d<\/jats:italic> = 1.35) compared to White participants. In stratified models, there was a negative indirect effect through depressive symptoms for Black participants [<jats:italic>\u03b2<\/jats:italic> = \u2212.074, 95% CI (\u2212.128, \u2212.029)] but not for White participants.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617723000474_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>These results highlight the need to consider racially patterned contextual factors across the life course. 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