{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:48:59Z","timestamp":1788058139430,"version":"build-2784847793"},"reference-count":77,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1355617724000596_as1\"><jats:title>Objective:<\/jats:title><jats:p>Identifying persons with HIV (PWH) at increased risk for Alzheimer\u2019s disease (AD) is complicated because memory deficits are common in HIV-associated neurocognitive disorders (HAND) and a defining feature of amnestic mild cognitive impairment (aMCI; a precursor to AD). Recognition memory deficits may be useful in differentiating these etiologies. Therefore, neuroimaging correlates of different memory deficits (i.e., recall, recognition) and their longitudinal trajectories in PWH were examined.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617724000596_as2\"><jats:title>Design:<\/jats:title><jats:p>We examined 92 PWH from the CHARTER Program, ages 45\u201368, without severe comorbid conditions, who received baseline structural MRI and baseline and longitudinal neuropsychological testing. Linear and logistic regression examined neuroanatomical correlates (i.e., cortical thickness and volumes of regions associated with HAND and\/or AD) of memory performance at baseline and multilevel modeling examined neuroanatomical correlates of memory decline (average follow-up = 6.5 years).<\/jats:p><\/jats:sec><jats:sec id=\"S1355617724000596_as3\"><jats:title>Results:<\/jats:title><jats:p>At baseline, thinner pars opercularis cortex was associated with impaired recognition (<jats:italic>p<\/jats:italic> = 0.012; <jats:italic>p<\/jats:italic> = 0.060 after correcting for multiple comparisons). Worse delayed recall was associated with thinner pars opercularis (<jats:italic>p<\/jats:italic> = 0.001) and thinner rostral middle frontal cortex (<jats:italic>p<\/jats:italic> = 0.006) cross sectionally even after correcting for multiple comparisons. Delayed recall and recognition were not associated with medial temporal lobe (MTL), basal ganglia, or other prefrontal structures. Recognition impairment was variable over time, and there was little decline in delayed recall. Baseline MTL and prefrontal structures were not associated with delayed recall.<\/jats:p><\/jats:sec><jats:sec id=\"S1355617724000596_as4\"><jats:title>Conclusions:<\/jats:title><jats:p>Episodic memory was associated with prefrontal structures, and MTL and prefrontal structures did not predict memory decline. There was relative stability in memory over time. Findings suggest that episodic memory is more related to frontal structures, rather than encroaching AD pathology, in middle-aged PWH. Additional research should clarify if recognition is useful clinically to differentiate aMCI and HAND.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1355617724000596","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T09:37:28Z","timestamp":1731663448000},"page":"966-976","source":"Crossref","is-referenced-by-count":1,"title":["The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV"],"prefix":"10.1017","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-1603","authenticated-orcid":false,"given":"Laura M.","family":"Campbell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fennema-Notestine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Sundermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Averi","family":"Barrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark W.","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert K.","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Morgello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal B.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Roesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7499-041X","authenticated-orcid":false,"given":"Raeanne C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"S1355617724000596_ref65","first-page":"717","volume-title":"Textbook of Clinical Neuropsychology","author":"Smith","year":"2016"},{"key":"S1355617724000596_ref6","doi-asserted-by":"crossref","unstructured":"Bates, D., M\u00e4chler, M., Bolker, B., & Walker, S. 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