{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:11:50Z","timestamp":1785413510890,"version":"3.56.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"7-8","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"unspecified","delay-in-days":81,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1355617725101318_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Everyday functional capacity in older adults is influenced by several factors, with prior studies finding that cognition mediates the relationship between depression and everyday functioning. However, these studies utilized samples with low depression severity and used only one type of functional assessment. We aimed to examine whether cognition mediates the relationship between depression and functioning in older adults with a history of treatment-resistant depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617725101318_as2\">\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Data from 383 participants enrolled in the OPTIMUM Neuro study were analyzed. Participants completed a neuropsychological assessment battery, depression severity interview, self-\/informant-rated functioning measures and a performance-based functioning measure. Linear regression was used to determine whether depression scores predicted cognitive domain and everyday functioning scores. Cognitive domain scores predicted by depression were then tested as mediators between depression and functioning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617725101318_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Higher depression symptoms predicted poorer performance on all measures of functioning as well as the cognitive domains of attention, executive functioning, and immediate memory. Immediate memory partially mediated the relationship between depression and a performance-based measure of functioning, while attention and executive functioning partially mediated the relationship between a self-report measure of functioning and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617725101318_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The relationship between depression severity and poorer functional performance was partially mediated by attention, executive functioning, and immediate memory, with results differing based on the measure of functioning used. Our findings suggest that there may be additional non-cognitive factors influencing this relationship and highlight the importance of using multiple methods to assess functional performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1355617725101318","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T07:00:00Z","timestamp":1761030000000},"page":"526-533","source":"Crossref","is-referenced-by-count":0,"title":["Everyday functioning in treatment-resistant late-life depression: The mediating role of cognition"],"prefix":"10.1017","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1287-671X","authenticated-orcid":false,"given":"Ashlyn","family":"Runk","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ect4e57","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrail","family":"Davis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ect4e57","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Lovato","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ect4e57","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Zhukovsky","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl A.","family":"Butters","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristotle","family":"Voineskos","sequence":"additional","affiliation":[{"name":"University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lavretsky","sequence":"additional","affiliation":[{"name":"University of California \u2013 Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Shimony","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brown","sequence":"additional","affiliation":[{"name":"Columbia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7252-7181","authenticated-orcid":false,"given":"Matthew","family":"Calamia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05ect4e57","id-type":"ROR","asserted-by":"publisher"}],"name":"Louisiana State University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"S1355617725101318_ref30","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01269-y"},{"key":"S1355617725101318_ref34","volume-title":"Mplus version 8 user\u2019s guide","author":"Muthen","year":"2017"},{"key":"S1355617725101318_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acy043"},{"key":"S1355617725101318_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2014.06.004"},{"key":"S1355617725101318_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610212000622"},{"key":"S1355617725101318_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.03.039"},{"key":"S1355617725101318_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2016.1161848"},{"key":"S1355617725101318_ref43","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2147\/NDT.S94643","article-title":"Mood disorders in the elderly: Prevalence, functional impact, and management challenges","volume":"12","author":"Valiengo","year":"2016","journal-title":"Neuropsychiatric Disease and Treatment"},{"key":"S1355617725101318_ref47","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12600"},{"key":"S1355617725101318_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.6.587"},{"key":"S1355617725101318_ref15","first-page":"1199","article-title":"Cognitive profiles in treatment-resistant late-life depression and their impact on treatment outcomes","volume":"9","author":"G\u00f6ke","year":"2024","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"S1355617725101318_ref18","volume-title":"Assessments in Occupational Therapy Mental Health","author":"Holm","year":"2008"},{"key":"S1355617725101318_ref28","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.12.2.277"},{"key":"S1355617725101318_ref9","unstructured":"Core Team R (2023). 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