{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T02:28:22Z","timestamp":1794536902217,"version":"4.9.1"},"reference-count":118,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":31,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S135561772610191X_as1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The quest for non-invasive and cost-effective biomarkers for mild cognitive impairment (MCI) and Alzheimer\u2019s disease (AD) has led to growing interest in resting-state functional magnetic resonance imaging (MRI). This study examined associations between whole-brain functional connectivity measures and cognitive performance across a spectrum of cognitive aging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S135561772610191X_as2\">\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A total of 108 older adults (mean age 74.1 \u00b1 5.7 years), comprised of cognitively intact individuals, participants with amnestic MCI, and those with mild dementia due to probable AD, underwent high-resolution structural MRI and resting-state functional MRI scans and cognitive testing with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Functional connectivity values were derived from a 17-network brain parcellation. Correlations were established between network connectivity values and RBANS Index scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S135561772610191X_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Analyses revealed that lower RBANS Attention Index and Total Scale scores were significantly associated with increased connectivity between the ventral attention, central executive network, and limbic and default mode networks. Lower RBANS total scores were also associated with functional connectivity strength between the dorsal default mode networks and lateral frontoparietal regions of the central executive network, with increased connectivity observed across the dementia spectrum (Intact-MCI-AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S135561772610191X_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings suggest that aberrant and potentially compensatory increases in functional connectivity may be linked to cognitive decline, supporting the utility of resting-state functional MRI as a promising biomarker for MCI and AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s135561772610191x","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:20:44Z","timestamp":1775038844000},"page":"255-266","source":"Crossref","is-referenced-by-count":1,"title":["Altered functional connectivity is associated with Repeatable Battery for the Assessment of Neuropsychological Status across the dementia spectrum"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0475","authenticated-orcid":false,"given":"Jace B.","family":"King","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly B.D.","family":"Prigge","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2036-7603","authenticated-orcid":false,"given":"Vincent","family":"Koppelmans","sequence":"additional","affiliation":[{"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Hoffman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r0ha626","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-2400","authenticated-orcid":false,"given":"Kevin","family":"Duff","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"S135561772610191X_ref96","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"S135561772610191X_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"S135561772610191X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.07.003"},{"key":"S135561772610191X_ref77","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-023-01117-y"},{"key":"S135561772610191X_ref51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047739"},{"key":"S135561772610191X_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"S135561772610191X_ref89","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.65.11.1467"},{"key":"S135561772610191X_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21079"},{"key":"S135561772610191X_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2014.992070"},{"key":"S135561772610191X_ref64","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4680972"},{"key":"S135561772610191X_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acu012"},{"key":"S135561772610191X_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2017.09.018"},{"key":"S135561772610191X_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.11.059"},{"key":"S135561772610191X_ref12","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00339.2011"},{"key":"S135561772610191X_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.09.018"},{"key":"S135561772610191X_ref110","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz129"},{"key":"S135561772610191X_ref20","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2015.1087596"},{"key":"S135561772610191X_ref33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.200033797"},{"key":"S135561772610191X_ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.036"},{"key":"S135561772610191X_ref78","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr072"},{"key":"S135561772610191X_ref17","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acq023"},{"key":"S135561772610191X_ref92","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.08.052"},{"key":"S135561772610191X_ref88","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.20.3.310.823"},{"key":"S135561772610191X_ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.06.029"},{"key":"S135561772610191X_ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"S135561772610191X_ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.09.039"},{"key":"S135561772610191X_ref98","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw253"},{"key":"S135561772610191X_ref58","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/act057"},{"key":"S135561772610191X_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2010.04.013"},{"key":"S135561772610191X_ref19","first-page":"40","article-title":"Cognitive complaints in older adults at risk for Alzheimer\u2019s disease are associated with altered resting-state networks","volume":"6","author":"Contreras","year":"2017","journal-title":"Alzheimer\u2019s and Dementia"},{"key":"S135561772610191X_ref90","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adp2564"},{"key":"S135561772610191X_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acu070"},{"key":"S135561772610191X_ref117","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23950"},{"key":"S135561772610191X_ref7","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000069923.64550.9F"},{"key":"S135561772610191X_ref74","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.09.036"},{"key":"S135561772610191X_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"S135561772610191X_ref113","volume-title":"WRAT. 4: Wide Range Achievement Test, professional manual","author":"Wilkinson","year":"2006"},{"key":"S135561772610191X_ref76","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116157"},{"key":"S135561772610191X_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.10.038"},{"key":"S135561772610191X_ref102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3067-17.2018"},{"key":"S135561772610191X_ref47","doi-asserted-by":"publisher","DOI":"10.1177\/1533317517698795"},{"key":"S135561772610191X_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.017"},{"key":"S135561772610191X_ref73","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"S135561772610191X_ref65","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00094"},{"key":"S135561772610191X_ref60","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24336"},{"key":"S135561772610191X_ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.052"},{"key":"S135561772610191X_ref100","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708803104"},{"key":"S135561772610191X_ref55","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000223"},{"key":"S135561772610191X_ref72","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2010.516769"},{"key":"S135561772610191X_ref44","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308627101"},{"key":"S135561772610191X_ref71","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57915-w"},{"key":"S135561772610191X_ref107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.07.044"},{"key":"S135561772610191X_ref43","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"S135561772610191X_ref63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1221536110"},{"key":"S135561772610191X_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acv052"},{"key":"S135561772610191X_ref104","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2021.2023476"},{"key":"S135561772610191X_ref101","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800005105"},{"key":"S135561772610191X_ref115","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"S135561772610191X_ref99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"S135561772610191X_ref106","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2015.1039962"},{"key":"S135561772610191X_ref87","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.07.006"},{"key":"S135561772610191X_ref49","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2013.827574"},{"key":"S135561772610191X_ref14","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2017.0509"},{"key":"S135561772610191X_ref108","volume-title":"Manual for the Weschler Memory Scale - Revised","author":"Wechsler","year":"1987"},{"key":"S135561772610191X_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4135"},{"key":"S135561772610191X_ref93","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu036"},{"key":"S135561772610191X_ref109","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2014.0234"},{"key":"S135561772610191X_ref91","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0080"},{"key":"S135561772610191X_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"S135561772610191X_ref103","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70191-6"},{"key":"S135561772610191X_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.020"},{"key":"S135561772610191X_ref37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604187103"},{"key":"S135561772610191X_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00569-X"},{"key":"S135561772610191X_ref38","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.8.1687"},{"key":"S135561772610191X_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.007"},{"key":"S135561772610191X_ref94","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"},{"key":"S135561772610191X_ref68","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2022.0008"},{"key":"S135561772610191X_ref46","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00474"},{"key":"S135561772610191X_ref50","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2382"},{"key":"S135561772610191X_ref82","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acr017"},{"key":"S135561772610191X_ref35","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhg087"},{"key":"S135561772610191X_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.024"},{"key":"S135561772610191X_ref57","first-page":"547","volume":"139","author":"Jones","year":"2016","journal-title":"Cascading network failure across the Alzheimer\u2019s disease spectrum. Brain"},{"key":"S135561772610191X_ref29","doi-asserted-by":"publisher","DOI":"10.1080\/13825585.2022.2124229"},{"key":"S135561772610191X_ref41","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu012"},{"key":"S135561772610191X_ref95","doi-asserted-by":"publisher","DOI":"10.1080\/09084280903297719"},{"key":"S135561772610191X_ref112","first-page":"152","article-title":"A robust biomarker of large-scale network failure in Alzheimer\u2019s disease","volume":"6","author":"Wiepert","year":"2017","journal-title":"Alzheimer\u2019s and Dementia: Diagnosis, Assessment and Disease Monitoring"},{"key":"S135561772610191X_ref1","unstructured":"ADNI2. Alzheimers Disease Neuroimaging Initiative: ADNI2 Procedures Manual. https:\/\/adni.loni.usc.edu\/wp-content\/uploads\/2008\/07\/adni2-procedures-manual.pdf."},{"key":"S135561772610191X_ref105","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.05.026"},{"key":"S135561772610191X_ref79","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101771"},{"key":"S135561772610191X_ref80","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.17"},{"key":"S135561772610191X_ref114","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"Journal of Neurophysiology"},{"key":"S135561772610191X_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2008.06.004"},{"key":"S135561772610191X_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/act047"},{"key":"S135561772610191X_ref118","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091701"},{"key":"S135561772610191X_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acq045"},{"key":"S135561772610191X_ref84","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2015.1107137"},{"key":"S135561772610191X_ref40","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-142547"},{"key":"S135561772610191X_ref83","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820af94e"},{"key":"S135561772610191X_ref48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1853-13.2014"},{"key":"S135561772610191X_ref45","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00770"},{"key":"S135561772610191X_ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.03.003"},{"key":"S135561772610191X_ref111","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm112"},{"key":"S135561772610191X_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000150"},{"key":"S135561772610191X_ref67","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-122212"},{"key":"S135561772610191X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.09.028"},{"key":"S135561772610191X_ref26","doi-asserted-by":"publisher","DOI":"10.1080\/13854046.2021.1995050"},{"key":"S135561772610191X_ref11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5698-11.2012"},{"key":"S135561772610191X_ref69","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acq028"},{"key":"S135561772610191X_ref42","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22379"},{"key":"S135561772610191X_ref30","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180847"},{"key":"S135561772610191X_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2024.101384"},{"key":"S135561772610191X_ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2010.03.003"},{"key":"S135561772610191X_ref5","first-page":"73","article-title":"Resting-state network dysfunction in Alzheimer\u2019s disease: a systematic review and meta-analysis","volume":"8","author":"Badhwar","year":"2017","journal-title":"Alzheimer\u2019s and Dementia"},{"key":"S135561772610191X_ref97","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000144"},{"key":"S135561772610191X_ref39","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160322141955"},{"key":"S135561772610191X_ref81","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2574-18.2019"},{"key":"S135561772610191X_ref86","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acw007"}],"container-title":["Journal of the International Neuropsychological Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S135561772610191X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T03:25:10Z","timestamp":1781148310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S135561772610191X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":118,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S135561772610191X"],"URL":"https:\/\/doi.org\/10.1017\/s135561772610191x","relation":{},"ISSN":["1355-6177","1469-7661"],"issn-type":[{"value":"1355-6177","type":"print"},{"value":"1469-7661","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]}}}