{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:06:16Z","timestamp":1790769976269,"version":"4.1.0"},"reference-count":69,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"unspecified","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Neuropsychol Soc"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S1355617726102082_as1\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) may represent the earliest observable stage of Alzheimer\u2019s disease (AD), yet identifying individuals at risk of progressing remains challenging. Cognitive dispersion, or intra-individual variability (IIV-D), may serve as a sensitive early marker. This study examined IIV-D across diagnostic groups, focusing on SCD and amnestic mild cognitive impairment (aMCI) progressors (SCD-p, aMCI-p; progressing to a more advanced disease stage) versus non-progressors (SCD-np, aMCI-np; not progressing to a more advanced stage). We expected greater IIV-D across groups (AD &gt; aMCI &gt; SCD &gt; controls) and in progressors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617726102082_as2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 308 participants aged 65\u201394 (67 healthy controls [HC], 126 SCD, 79 aMCI, 36 AD) from the Consortium for the Early Identification of Alzheimer\u2019s Disease \u2013 Quebec (CIMA-Q) were included. SCD and aMCI participants were followed for up to eight years (34 SCD-p, 92 SCD-np; 29 aMCI-p, 50 aMCI-np). Analyses of covariance assessed baseline across- and verbal memory within-domain IIV-D, maximum discrepancy (MD), and domain-specific deviation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617726102082_as3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>IIV-D increased with disease severity (HC = SCD &lt; aMCI &lt; AD). Among SCD participants, progressors showed greater episodic memory deviation than non-progressors, primarily driven by poorer Logical Memory delayed recall. In aMCI, progressors showed higher IIV-D across all indices (across- and within-domain, IIV-D and MD), with domain-specific differences limited to episodic memory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S1355617726102082_as4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These findings indicate that IIV-D measures distinguish aMCI progressors from non-progressors, although they do not appear to enhance predictive accuracy for progression to AD and may not yet be a reliable marker at the SCD stage.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s1355617726102082","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:58:02Z","timestamp":1782284282000},"page":"363-374","source":"Crossref","is-referenced-by-count":0,"title":["Cognitive dispersion in the Alzheimer\u2019s disease spectrum"],"prefix":"10.1017","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1878-8688","authenticated-orcid":false,"given":"Justine","family":"Marsault","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 de Montr\u00e9al"},{"id":[{"id":"https:\/\/ror.org\/031z68d90","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre de recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume T.","family":"Vallet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/031z68d90","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre de recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al"},{"name":"Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Joubert","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 de Montr\u00e9al"},{"id":[{"id":"https:\/\/ror.org\/031z68d90","id-type":"ROR","asserted-by":"publisher"}],"name":"Centre de recherche de l\u2019Institut Universitaire de G\u00e9riatrie de Montr\u00e9al"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CIMA-Q group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"S1355617726102082_ref20","first-page":"1","article-title":"The utility of global versus domain-specific neuropsychological test score dispersion as markers of cognitive impairment","author":"Fatima","year":"2025","journal-title":"The Clinical Neuropsychologist"},{"key":"S1355617726102082_ref55","volume-title":"BORB: Birmingham Object Recognition Battery","author":"Riddoch","year":"1993"},{"key":"S1355617726102082_ref6","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000242734.16663.09"},{"key":"S1355617726102082_ref46","doi-asserted-by":"publisher","DOI":"10.4097\/kja.21209"},{"key":"S1355617726102082_ref37","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000856"},{"key":"S1355617726102082_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05718-5"},{"key":"S1355617726102082_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"S1355617726102082_ref42","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0910-3"},{"key":"S1355617726102082_ref69","doi-asserted-by":"publisher","DOI":"10.1037\/t49755-000"},{"key":"S1355617726102082_ref52","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150729"},{"key":"S1355617726102082_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21509"},{"key":"S1355617726102082_ref70","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(82)90033-4"},{"key":"S1355617726102082_ref60","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180229"},{"key":"S1355617726102082_ref38","doi-asserted-by":"publisher","DOI":"10.1037\/a0017798"},{"key":"S1355617726102082_ref47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"S1355617726102082_ref5","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000532"},{"key":"S1355617726102082_ref66","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200514"},{"key":"S1355617726102082_ref36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"S1355617726102082_ref4","unstructured":"Army Individual Test Battery. 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