{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:24:31Z","timestamp":1791113071419,"version":"4.1.0"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980008003145_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>To study the effect of combining multiple (two or more) micronutrients with Fe supplementation on Hb response, when compared with placebo and with Fe supplementation, in children.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003145_abs2\" sec-type=\"general\"><jats:title>Data sources<\/jats:title><jats:p>Electronic databases, personal files, hand search of reviews, bibliographies of books, and abstracts and proceedings of international conferences.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003145_abs3\" sec-type=\"general\"><jats:title>Review methods<\/jats:title><jats:p>Randomized controlled trials evaluating change in Hb levels with interventions that included Fe and multiple-micronutrient supplementation in comparison to placebo alone or Fe alone were analysed in two systematic reviews.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003145_abs4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Twenty-five trials were included in the review comparing Fe and micronutrient supplementation with placebo. The pooled estimate (random effects model) for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0\u00b765 g\/dl (95 % CI 0\u00b750, 0\u00b780,<jats:italic>P<\/jats:italic>&lt; 0\u00b7001). Lower baseline Hb, lower height-for-age<jats:italic>Z<\/jats:italic>score, non-intake of \u2018other micronutrients\u2019 and malarial non-hyperendemic region were significant predictors of greater Hb response and heterogeneity. Thirteen trials were included in the review comparing Fe and micronutrient supplementation with Fe alone. The pooled estimate for change in Hb with Fe and micronutrient supplementation (weighted mean difference) was 0\u00b714 g\/dl (95 % CI 0\u00b700, 0\u00b728,<jats:italic>P<\/jats:italic>= 0\u00b704). None of the variables were found to be significant predictors of Hb response.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003145_abs5\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Synthesized evidence indicates that addition of multiple micronutrients to Fe supplementation may only marginally improve Hb response compared with Fe supplementation alone. However, addition of \u2018other micronutrients\u2019 may have a negative effect. Routine addition of unselected multiple micronutrients to Fe therefore appears unjustified for nutritional anaemia control programmes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980008003145","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T09:47:33Z","timestamp":1217584053000},"page":"756-773","source":"Crossref","is-referenced-by-count":25,"title":["Effect of combining multiple micronutrients with iron supplementation on Hb response in children: systematic review of randomized controlled trials"],"prefix":"10.1017","volume":"12","author":[{"given":"Tarun","family":"Gera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh Pal Singh","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Nestel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"S1368980008003145_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.1.80"},{"key":"S1368980008003145_ref56","volume-title":"Human Nutrition in the Developing World","author":"Latham","year":"1997"},{"key":"S1368980008003145_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000243440.85452.38"},{"key":"S1368980008003145_ref4","volume-title":"Efficacy of Intermittent Iron Supplementation in the Control of Iron Deficiency Anemia in Developing Countries: An Analysis of Experience","author":"Beaton","year":"1999"},{"key":"S1368980008003145_ref28","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19940062"},{"key":"S1368980008003145_ref50","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.646S"},{"key":"S1368980008003145_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/21.1.57"},{"key":"S1368980008003145_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/47.3.413"},{"key":"S1368980008003145_ref21","first-page":"895","article-title":"Running performance in Gambian children: effects of water soluble vitamins or iron","volume":"42","author":"Powers","year":"1988","journal-title":"Eur J Clin Nutr"},{"key":"S1368980008003145_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.5.876"},{"key":"S1368980008003145_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/9780470693926.ch18"},{"key":"S1368980008003145_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/51.3.436"},{"key":"S1368980008003145_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.9.2187"},{"key":"S1368980008003145_ref49","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.653S"},{"key":"S1368980008003145_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/57.4.506"},{"key":"S1368980008003145_ref19","first-page":"427","article-title":"Effects of a multivitamin and iron supplement on running performance in Gambian children","volume":"39C","author":"Power","year":"1985","journal-title":"Hum Nutr Clin Nutr"},{"key":"S1368980008003145_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/9780470693926.ch11"},{"key":"S1368980008003145_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/66.1.177"},{"key":"S1368980008003145_ref12","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1985.34.519"},{"key":"S1368980008003145_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)04229-3"},{"key":"S1368980008003145_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.4.921"},{"key":"S1368980008003145_ref43","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.4.891"},{"key":"S1368980008003145_ref34","first-page":"261","article-title":"Identification of an appropriate strategy to control anemia in adolescent girls of poor communities","volume":"37","author":"Sharma","year":"2000","journal-title":"Indian Pediatr"},{"key":"S1368980008003145_ref52","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67963-4"},{"key":"S1368980008003145_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90244-6"},{"key":"S1368980008003145_ref18","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/28.7.721"},{"key":"S1368980008003145_ref11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.2943111.x"},{"key":"S1368980008003145_ref22","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2005782"},{"key":"S1368980008003145_ref57","first-page":"A76","article-title":"The role of race and poverty in access to foods that enable individuals to adhere to dietary guidelines","volume":"3","author":"Baker","year":"2006","journal-title":"Prev Chronic Dis"},{"key":"S1368980008003145_ref1","volume-title":"Fourth Report on the World Nutrition Situation","year":"2000"},{"key":"S1368980008003145_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2554-7_24"},{"key":"S1368980008003145_ref61","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39150.510475.AE"},{"key":"S1368980008003145_ref2","unstructured":"2. International Institute for Population Sciences (2007) National Family Health Survey (NFHS-3), India, 2005\u20136. Mumbai: International Institute for Population Sciences."},{"key":"S1368980008003145_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.5.1032"},{"key":"S1368980008003145_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(92)90054-Q"},{"key":"S1368980008003145_ref29","first-page":"325","article-title":"The effects of high energy and micronutrient supplementation on iron status in nutritionally at risk infants","volume":"9","author":"Husaini","year":"1996","journal-title":"Biomed Environ Sci"},{"key":"S1368980008003145_ref26","first-page":"1119","article-title":"Prevention of iron deficiency by milk fortification III. Effectiveness under the usual operational conditions of a nation-wide food program","volume":"38","author":"Stekel","year":"1988","journal-title":"Nutr Rep Int"},{"key":"S1368980008003145_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.2874"},{"key":"S1368980008003145_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1034"},{"key":"S1368980008003145_ref38","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.1.108"},{"key":"S1368980008003145_ref39","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001179"},{"key":"S1368980008003145_ref42","doi-asserted-by":"publisher","DOI":"10.1080\/0963748031000092161"},{"key":"S1368980008003145_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/9780470693926.ch5"},{"key":"S1368980008003145_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.4.903"},{"key":"S1368980008003145_ref48","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.660S"},{"key":"S1368980008003145_ref51","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.3.639S"},{"key":"S1368980008003145_ref54","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.4.883"},{"key":"S1368980008003145_ref58","doi-asserted-by":"publisher","DOI":"10.1080\/02724936.1982.11748250"},{"key":"S1368980008003145_ref59","volume-title":"Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia","year":"1988"},{"key":"S1368980008003145_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/59.2.492S"},{"key":"S1368980008003145_ref60","doi-asserted-by":"publisher","DOI":"10.1301\/00296640260130858"},{"key":"S1368980008003145_ref40","first-page":"49","article-title":"The effectiveness of weekly iron and vitamin supplementation of Malawian preschool children","volume":"91","author":"Young","year":"2001","journal-title":"S Afr Med J"},{"key":"S1368980008003145_ref35","doi-asserted-by":"publisher","DOI":"10.1080\/07430170120093508"},{"key":"S1368980008003145_ref53","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.3.580"},{"key":"S1368980008003145_ref41","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.64.164"},{"key":"S1368980008003145_ref9","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0308-2261(21)00302-7","article-title":"Nutritional anemias. Part 2: tropical Asia","volume":"10","author":"Baker","year":"1981","journal-title":"Clin Haematol"},{"key":"S1368980008003145_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.5.1276"},{"key":"S1368980008003145_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.4.973"},{"key":"S1368980008003145_ref13","volume-title":"The Cochrane Library","author":"Clarke","year":"2001"},{"key":"S1368980008003145_ref33","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00626.x"},{"key":"S1368980008003145_ref55","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19980020"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980008003145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T05:29:02Z","timestamp":1631597342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980008003145\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S1368980008003145"],"URL":"https:\/\/doi.org\/10.1017\/s1368980008003145","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}