{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:21:58Z","timestamp":1790893318780,"version":"4.1.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980008003479_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>To assess the folate and vitamin B<jats:sub>12<\/jats:sub>status of a group of Vietnamese women of reproductive age and to estimate the rate of neural tube defects (NTD) based on red blood cell (RBC) folate concentrations.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003479_abs2\" sec-type=\"general\"><jats:title>Design and subjects<\/jats:title><jats:p>A representative sample of non-pregnant women (15\u201349 years) living in Hanoi City (<jats:italic>n<\/jats:italic>244) and Hai Duong Province (<jats:italic>n<\/jats:italic>245).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003479_abs3\" sec-type=\"general\"><jats:title>Measures<\/jats:title><jats:p>RBC folate, plasma vitamin B<jats:sub>12<\/jats:sub>and plasma holo-transcobalamin (holoTC), a sensitive indicator of vitamin B<jats:sub>12<\/jats:sub>status.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003479_abs4\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Mean (95 % CI) concentrations of RBC folate, plasma B<jats:sub>12<\/jats:sub>and plasma holoTC were 856 (837, 876) nmol\/l, 494 (475, 513) pmol\/l and 78 (74, 82) pmol\/l, respectively. Only 3 % and 4 % of women had plasma B<jats:sub>12<\/jats:sub>and holoTC concentrations indicative of deficiency. No woman had an RBC folate concentration indicative of deficiency (&lt;317 nmol\/l). Only 47 % of women had an RBC folate concentration \u2265905 nmol\/l. Accordingly, we predict the NTD rate in these regions of Vietnam to be 14\u00b77 (14\u00b72, 15\u00b71) per 10 000 pregnancies.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980008003479_abs5\" sec-type=\"conclusion\"><jats:title>Conclusion<\/jats:title><jats:p>There was no evidence of folate and vitamin B<jats:sub>12<\/jats:sub>deficiency among this population of Vietnamese women. However, suboptimal folate status may be placing three out of five women at increased risk of NTD. Reductions in NTD rates are still possible and women would benefit from additional folic acid during the periconceptional period from either supplements or fortified foods.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980008003479","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T13:02:47Z","timestamp":1219842167000},"page":"941-946","source":"Crossref","is-referenced-by-count":9,"title":["Folate and vitamin B<sub>12<\/sub>status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam"],"prefix":"10.1017","volume":"12","author":[{"given":"Vu Thi Thu","family":"Hien","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen 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