{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:51:48Z","timestamp":1790333508674,"version":"4.1.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T00:00:00Z","timestamp":1271894400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980010000820_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To investigate the efficacy of biscuits fortified with different doses of vitamin A on improving vitamin A deficiency (VAD), anaemia and physical growth of pre-school children.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010000820_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>A randomised double-masked population-based field interventional trial with a positive control group.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010000820_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Banan district of Chongqing, China.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010000820_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>A total of 580 pre-school children aged 3\u20136 years were randomly recruited into four groups. Children in groups I and II were given biscuits fortified with vitamin A at 30 % of the recommended daily intake (RDA) and 100 % of the RDA once a day for 9 and 3 months, respectively. Children in group III received biscuits containing 20 000 IU of vitamin A once a week for 3 months. Initially, the children in group IV received a 200 000 IU vitamin A capsule just once. At the beginning and end of the study, blood samples were collected to measure Hb, serum retinol, retinol-binding protein and prealbumin, and weight and height were measured.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010000820_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>All the fortification types significantly decreased the prevalence of VAD and anaemia in each group (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). The effect of 9-month intervention on group I was the most efficient (<jats:italic>P<\/jats:italic> &lt; 0\u00b70045). After intervention, the <jats:italic>Z<\/jats:italic>-scores of height-for-age, weight-for-age and weight-for-height in all groups increased markedly compared with baseline (<jats:italic>P<\/jats:italic> &lt; 0\u00b705), but no significant difference was observed among the groups.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010000820_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Data indicated that consuming vitamin A-fortified biscuits with daily 100 % RDA for 3 months has the same effect on the improvement of VAD, anaemia and physical growth as did the weekly 20 000 IU and single 200 000 IU administration in pre-school children.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980010000820","type":"journal-article","created":{"date-parts":[[2010,4,22]],"date-time":"2010-04-22T13:59:09Z","timestamp":1271944749000},"page":"1462-1471","source":"Crossref","is-referenced-by-count":18,"title":["Effect of biscuits fortified with different doses of vitamin A on indices of vitamin A status, haemoglobin and physical growth levels of pre-school children in Chongqing"],"prefix":"10.1017","volume":"13","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Xue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"S1368980010000820_ref32","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113721"},{"key":"S1368980010000820_ref30","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.75.3.187"},{"key":"S1368980010000820_ref27","first-page":"62","article-title":"Effect of zinc added to multi-vitamin supplementation containing low-dose vitamin A on plasma retinol level in children \u2013 a double-blind randomized, controlled trial","volume":"25","author":"Sazawal","year":"2007","journal-title":"J Health Popul Nutr"},{"key":"S1368980010000820_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg208"},{"key":"S1368980010000820_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2001.tb03237.x"},{"key":"S1368980010000820_ref15","first-page":"1","article-title":"CDC growth charts: United States","author":"Kuczmarski","year":"2000","journal-title":"Adv Data"},{"key":"S1368980010000820_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1998)12:3<137::AID-JCLA2>3.0.CO;2-6"},{"key":"S1368980010000820_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2257.1987.tb01384.x"},{"key":"S1368980010000820_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.3.497"},{"key":"S1368980010000820_ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00493.x"},{"key":"S1368980010000820_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.9.2902S"},{"key":"S1368980010000820_ref2","first-page":"762","article-title":"Analysis on the changes of nutritional situation in past 15 years (1990\u20132005) in China: the 15-year establishment of Chinese food and nutrition surveillance system (CFNSS)","volume":"35","author":"Chen","year":"2006","journal-title":"Wei Sheng Yan Jiu"},{"key":"S1368980010000820_ref1","first-page":"230","article-title":"The world health report 2002 \u2013 reducing risks, promoting healthy life","volume":"16","author":"Guilbert","year":"2003","journal-title":"Educ Health (Abingdon)"},{"key":"S1368980010000820_ref31","doi-asserted-by":"publisher","DOI":"10.1191\/0748233705th225oa"},{"key":"S1368980010000820_ref17","volume-title":"Indicators for Assessing vitamin A Deficiency and Their Application in Monitoring and Evaluating Intervention Programmes. 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