{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:34:20Z","timestamp":1791160460890,"version":"4.1.0"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980010002739_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To determine whether frequent vitamin C supplement use is associated with healthier behaviours, and a history of cancer and other illnesses in UK women.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010002739_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>The present cross-sectional analysis examines the odds of taking supplements containing vitamin C as recorded in 4 d food diaries, based on lifestyle characteristics and morbidity history self-reported by questionnaire.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010002739_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>A large national UK cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010002739_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>A total of 12 453 women aged between 37 and 79 years.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010002739_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Women frequently taking supplements containing vitamin C, compared to those who did not, had healthier behaviours, including higher consumption of fruit and vegetables. Frequent high-dose vitamin C users (\u22651000 mg) had a higher socio-economic status, visited alternative practitioners more often than family or private doctors, and were more likely to be ex-smokers and to drink little or no alcohol. Women who self-reported having had cancer (OR = 1\u00b733, 95 % CI 1\u00b700, 1\u00b776) or specifically breast cancer (OR = 1\u00b770, 95 % CI 1\u00b714, 2\u00b755), or reported a family history of cancer (OR = 1\u00b716, 95 % CI 0\u00b795, 1\u00b741) or breast cancer (OR = 1\u00b726, 95 % CI 1\u00b701, 1\u00b758) had increased odds of being frequent high-dose users after adjusting for sociodemographic and health behaviours. Women with personal or family histories of some cardiovascular or intestinal disorders were more likely to take supplements containing vitamin C, though not necessarily at high doses.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980010002739_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>High-dose vitamin C intake by UK women was associated with healthier behaviours and a history of breast cancer, total cancer and other illnesses. Consequences of high-dose vitamin C supplement intake are not clear at the population level.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980010002739","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T06:08:50Z","timestamp":1288332530000},"page":"768-777","source":"Crossref","is-referenced-by-count":21,"title":["High-dose vitamin C supplement use is associated with self-reported histories of breast cancer and other illnesses in the UK Women\u2019s Cohort Study"],"prefix":"10.1017","volume":"14","author":[{"given":"Jayne","family":"Hutchinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria J","family":"Burley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren C","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E","family":"Cade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,10,29]]},"reference":[{"key":"S1368980010002739_ref49","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.261"},{"key":"S1368980010002739_ref51","first-page":"1","article-title":"Opinion of the scientific panel on dietetic products, nutrition and allergies on a request from the commission related to the tolerable upper intake level of vitamin C (L-ascorbic acid, its calcium, potassium and sodium salts and L-ascorbyl-6-palmitate)","volume":"59","year":"2004","journal-title":"EPSA J"},{"key":"S1368980010002739_ref43","volume-title":"Diet, Nutrition and the Prevention of Chronic Diseases WHO Technical Report Series","year":"1990"},{"key":"S1368980010002739_ref21","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5905"},{"key":"S1368980010002739_ref44","volume-title":"Food, Nutrition and the Prevention of Cancer: A Global Perspective","year":"1997"},{"key":"S1368980010002739_ref48","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf205"},{"key":"S1368980010002739_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.5.909"},{"key":"S1368980010002739_ref40","first-page":"29","article-title":"Vitamin\/mineral supplementation among cancer survivors: 1987 and 1992 National Health Interview Surveys","volume":"41","author":"McDavid","year":"2001","journal-title":"Nutr Cancer"},{"key":"S1368980010002739_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980099000099"},{"key":"S1368980010002739_ref38","first-page":"323","article-title":"Changes in diet, physical activity, and supplement use among adults diagnosed with cancer","volume":"103","author":"Patterson","year":"2003","journal-title":"J Am Diet Assoc"},{"key":"S1368980010002739_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(00)00165-9"},{"key":"S1368980010002739_ref33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909273011303"},{"key":"S1368980010002739_ref23","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2004620"},{"key":"S1368980010002739_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00575-8"},{"key":"S1368980010002739_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605023341803"},{"key":"S1368980010002739_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.12.2355"},{"key":"S1368980010002739_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.7.1782"},{"key":"S1368980010002739_ref7","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20031076"},{"key":"S1368980010002739_ref5","unstructured":"5. 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