{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:22:29Z","timestamp":1770902549947,"version":"3.50.1"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980011000140_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To investigate genetic and lifestyle factors and their interactions on plasma homocysteine (Hcy) concentrations in the Boston Puerto Rican population.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011000140_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Cross-sectional study. Plasma concentrations of Hcy, folate, vitamin B<jats:sub>12<\/jats:sub>and pyridoxal phosphate were measured, and genetic polymorphisms were determined. Data on lifestyle factors were collected in interviews.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011000140_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>A population survey of health and nutritional measures.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011000140_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>A total of 994 Puerto Rican men and women residing in the Boston metropolitan area.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011000140_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Smoking status was positively associated with plasma Hcy. Genetic polymorphisms<jats:italic>MTHFR<\/jats:italic>677C\u2192T,<jats:italic>FOLH1<\/jats:italic>1561C\u2192T,<jats:italic>FOLH1<\/jats:italic>rs647370 and<jats:italic>PCFT<\/jats:italic>928A\u2192G interacted significantly with smoking for Hcy.<jats:italic>MTHFR<\/jats:italic>1298A\u2192C (<jats:italic>P<\/jats:italic>= 0\u00b7040) and<jats:italic>PCFT<\/jats:italic>928A\u2192G (<jats:italic>P<\/jats:italic>= 0\u00b7002) displayed significant interactions with alcohol intake in determining plasma Hcy. Subjects with<jats:italic>PCFT<\/jats:italic><jats:italic>928GG<\/jats:italic>genotype had significantly higher plasma Hcy concentrations compared with carriers of the<jats:italic>A<\/jats:italic>allele (<jats:italic>AA<\/jats:italic>+<jats:italic>AG<\/jats:italic>;<jats:italic>P<\/jats:italic>= 0\u00b7030) among non-drinking subjects. When consuming alcohol,<jats:italic>GG<\/jats:italic>subjects had lower plasma Hcy levels compared with<jats:italic>AA<\/jats:italic>+<jats:italic>AG<\/jats:italic>subjects. Physical activity interacted significantly with<jats:italic>MTR<\/jats:italic>2756A\u2192G in determining plasma Hcy (<jats:italic>P<\/jats:italic>for interaction = 0\u00b7002). Smoking interacted with physical activity for plasma Hcy (<jats:italic>P<\/jats:italic>for interaction = 0\u00b7023).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011000140_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Smoking and drinking were associated plasma Hcy concentrations. Genetic variants involved in folate metabolism further modify the effects of lifestyle on plasma Hcy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980011000140","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T11:07:41Z","timestamp":1298372861000},"page":"1805-1812","source":"Crossref","is-referenced-by-count":14,"title":["Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population"],"prefix":"10.1017","volume":"14","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine L","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy 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