{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T04:48:35Z","timestamp":1788410915448,"version":"build-2803163510"},"reference-count":57,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:00:00Z","timestamp":1315267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980011001765_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To examine the associations between near and distant visual acuity and biomarkers of Hg, Pb, <jats:italic>n<\/jats:italic>-3 fatty acids and Se from the local diet of fish-eating communities of the Tapaj\u00f3s River in the Brazilian Amazon.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011001765_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Visuo-ocular health and biomarkers of Hg (hair, whole blood, plasma), Pb (whole blood), Se (whole blood and plasma) and <jats:italic>n<\/jats:italic>-3 fatty acids (plasma total phospholipids) were assessed in a cross-sectional study.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011001765_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Lower Tapaj\u00f3s River Basin (State of Par\u00e1, Brazil), May to July 2006.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011001765_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Two hundred and forty-three adults (\u226515 years) without diagnosed age-related cataracts or ocular pathologies.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011001765_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Near visual acuity was negatively associated with hair Hg and positively associated with %DHA, with a highly significant Log Hg \u00d7 age interaction term. Stratifying for age showed that while young people presented good acuity, for those aged \u226540 years, clinical presbyopia was associated with hair Hg \u2265 15 \u03bcg\/g (OR = 3\u00b793, 95 % CI 1\u00b725, 14\u00b718) and %DHA (OR = 0\u00b737, 95 % CI 0\u00b711, 1\u00b711). A similar age-related pattern was observed for distant visual acuity in relation to blood Pb, but the evidence was weaker.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011001765_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that Hg and Pb may affect visual acuity in older persons, while DHA appears to be protective for near visual acuity loss. In this population, with little access to eye care, diet may have an important influence on visuo-ocular ageing.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980011001765","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T14:50:44Z","timestamp":1315320644000},"page":"2236-2244","source":"Crossref","is-referenced-by-count":21,"title":["Visual acuity in fish consumers of the Brazilian Amazon: risks and benefits from local diet"],"prefix":"10.1017","volume":"14","author":[{"given":"Myriam","family":"Fillion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Lemire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Philibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope Alberta","family":"Weiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Robert","family":"Deguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Remy Dav\u00e9e","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Larribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Fernando","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mergler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,9,6]]},"reference":[{"key":"S1368980011001765_ref57","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.041210"},{"key":"S1368980011001765_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(93)90218-L"},{"key":"S1368980011001765_ref52","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11268"},{"key":"S1368980011001765_ref49","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-04-00994.1991"},{"key":"S1368980011001765_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2007.08.023"},{"key":"S1368980011001765_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2007.07.008"},{"key":"S1368980011001765_ref44","doi-asserted-by":"publisher","DOI":"10.1136\/fn.88.5.F383"},{"key":"S1368980011001765_ref42","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2006.may.S24-S33"},{"key":"S1368980011001765_ref41","doi-asserted-by":"publisher","DOI":"10.1080\/10408440600845619"},{"key":"S1368980011001765_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90125-7"},{"key":"S1368980011001765_ref38","first-page":"57","volume-title":"Congenital and Acquired Color Vision Defects","author":"Pokorny","year":"1979"},{"key":"S1368980011001765_ref35","unstructured":"35. International Council of Ophthalmology (2002) Visual Standards \u2013 Aspects and Ranges of Vision Loss with Emphasis on Population Surveys. Sydney: ICO."},{"key":"S1368980011001765_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2006.03.023"},{"key":"S1368980011001765_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.03.016"},{"key":"S1368980011001765_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/5.1.47"},{"key":"S1368980011001765_ref28","doi-asserted-by":"publisher","DOI":"10.1579\/0044-7447(2007)36[3:MEAHEI]2.0.CO;2"},{"key":"S1368980011001765_ref23","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901284"},{"key":"S1368980011001765_ref19","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2008.14"},{"key":"S1368980011001765_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.03.005"},{"key":"S1368980011001765_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/biof.42"},{"key":"S1368980011001765_ref12","first-page":"20","article-title":"Omega 3 fatty acids and the eye","volume":"33","author":"Cakiner-Egilmez","year":"2008","journal-title":"Insight"},{"key":"S1368980011001765_ref10","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2008001600004"},{"key":"S1368980011001765_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2010.03.011"},{"key":"S1368980011001765_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2006.05.004"},{"key":"S1368980011001765_ref6","first-page":"157","article-title":"Evidence of early nervous system dysfunction in Amazonian populations exposed to low levels of methylmercury","volume":"17","author":"Lebel","year":"1996","journal-title":"Neurotoxicology"},{"key":"S1368980011001765_ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.65.4.284"},{"key":"S1368980011001765_ref4","first-page":"1127","article-title":"Representation of the visual field in the striate cortex: comparison of MR findings with visual field deficits in organic mercury poisoning (Minamata disease)","volume":"18","author":"Korogi","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"S1368980011001765_ref2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9310031"},{"key":"S1368980011001765_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2005.08.057"},{"key":"S1368980011001765_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2005.06.026"},{"key":"S1368980011001765_ref40","first-page":"1","article-title":"Ocular disorders among workers exposed to mercury","volume":"70","author":"Gabal","year":"1995","journal-title":"J Egypt Public Health Assoc"},{"key":"S1368980011001765_ref37","first-page":"121","volume-title":"Vision and Aging: General and Clinical Perspectives","author":"Morgan","year":"1986"},{"key":"S1368980011001765_ref1","doi-asserted-by":"publisher","DOI":"10.1006\/enrs.1998.3846"},{"key":"S1368980011001765_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-0958-3"},{"key":"S1368980011001765_ref27","first-page":"255","article-title":"Establishment and analytical quality control of laboratories for Hg determination in biological and geological samples in the Amazon \u2013 Brazil","volume":"50","author":"Bastos","year":"1998","journal-title":"Ci\u00eancia e Cultura"},{"key":"S1368980011001765_ref53","doi-asserted-by":"publisher","DOI":"10.1016\/0531-5565(86)90047-1"},{"key":"S1368980011001765_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.sab.2006.09.001"},{"key":"S1368980011001765_ref22","first-page":"89","article-title":"Selenium, selenoproteins and vision","volume":"38","author":"Flohe","year":"2005","journal-title":"Dev Ophthalmol"},{"key":"S1368980011001765_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2009.05.003"},{"key":"S1368980011001765_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(86)90125-2"},{"key":"S1368980011001765_ref17","first-page":"767","article-title":"Comparison of visual function at adulthood and during aging in monkeys exposed to lead or methylmercury","volume":"20","author":"Rice","year":"1999","journal-title":"Neurotoxicology"},{"key":"S1368980011001765_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2005.12.005"},{"key":"S1368980011001765_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2007.01.012"},{"key":"S1368980011001765_ref33","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.152694"},{"key":"S1368980011001765_ref46","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.6.1292"},{"key":"S1368980011001765_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1458S"},{"key":"S1368980011001765_ref51","first-page":"623","article-title":"Persistent decrease of the dopamine-synthesizing enzyme tyrosine hydroxylase in the rhesus monkey retina after chronic lead exposure","volume":"18","author":"Kohler","year":"1997","journal-title":"Neurotoxicology"},{"key":"S1368980011001765_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20471"},{"key":"S1368980011001765_ref25","unstructured":"25. CARUSO (2011) Mercury exposure and ecosystem health in the Amazon. http:\/\/www.unites.uqam.ca\/gmf\/caruso\/caruso_home.htm (accessed January 2011)."},{"key":"S1368980011001765_ref11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-3640"},{"key":"S1368980011001765_ref34","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.151852"},{"key":"S1368980011001765_ref36","volume-title":"The Human Nervous System: Structure and Function","author":"Noback","year":"2005"},{"key":"S1368980011001765_ref56","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652009000300017"},{"key":"S1368980011001765_ref54","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.126.8.1111"},{"key":"S1368980011001765_ref24","first-page":"141","article-title":"Natural therapies for ocular disorders, part two: cataracts and glaucoma","volume":"6","author":"Head","year":"2001","journal-title":"Altern Med Rev"},{"key":"S1368980011001765_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.9.2307"},{"key":"S1368980011001765_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2010.05.022"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980011001765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T03:16:52Z","timestamp":1556335012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980011001765\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,6]]},"references-count":57,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S1368980011001765"],"URL":"https:\/\/doi.org\/10.1017\/s1368980011001765","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,6]]}}}