{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:55:05Z","timestamp":1773320105650,"version":"3.50.1"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980011003181_abs1\" sec-type=\"general\"><jats:title>Objectives<\/jats:title><jats:p>To study the clinico-immunological, nutritional and growth characteristics of HIV-infected children and the impact of antiretroviral therapy (ART) on these parameters.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011003181_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011003181_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Out-patient department of a paediatric ART centre, Delhi, India.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011003181_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>HIV-positive children registered at the paediatric ART centre of the hospital were enrolled (<jats:italic>n<\/jats:italic> 130). Anthropometric measurements were used to classify children into the type of malnutrition according to definitions of the WHO and US Centers for Disease Control and Prevention. Clinical and immunological status of the children was recorded as per WHO guidelines. First-line ART was started based on guidelines of the National AIDS Control Organization. Nutritional status and clinico-immunological characteristics were followed up annually in children receiving ART.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011003181_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Of children \u22645 years of age (<jats:italic>n<\/jats:italic> 54), stunting was noted in 42\u00b75 % contrary to wasting seen in only 12\u00b79 %. In children &gt;5 years of age (<jats:italic>n<\/jats:italic> 76), short stature (40\u00b77 %) and underweight (39\u00b74 %) were seen in almost equal proportions. Asymptomatic presentation was noted in 60\u00b70 %. Following ART, a reduction in wasting was noted in 75\u00b70 % of children \u22645 years of age, whereas only 44\u00b74 % of underweight children &gt;5 years of age showed an improvement after therapy. Stunting and short stature continued to persist in all in children (\u22645 years and &gt;5 years, respectively). Clinico-immunologically, 67\u00b75 % improved in clinical status and 62\u00b75 % showed immunological improvement.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980011003181_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>ART improves the acute parameters of nutritional status like wasting. It also improves the clinical outcome and restores the immune system. At present first-line ART is effective in HIV-positive children.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980011003181","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T10:16:07Z","timestamp":1333448167000},"page":"1442-1445","source":"Crossref","is-referenced-by-count":4,"title":["Clinico-immunological profile and outcome of antiretroviral therapy in HIV-positive children"],"prefix":"10.1017","volume":"15","author":[{"given":"Nidhi","family":"Choudhary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Gomber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Narang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,4,3]]},"reference":[{"key":"S1368980011003181_ref6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2008.142646"},{"key":"S1368980011003181_ref2","first-page":"239","article-title":"Clinical profile of HIV infection","volume":"38","author":"Merchant","year":"2001","journal-title":"Indian Pediatr"},{"key":"S1368980011003181_ref8","volume-title":"Nutrition and HIV\/AIDS: Evidence, Gaps and Priority Actions. Support for Analysis and Research in Africa (SARA) Project","author":"Piwoz","year":"2004"},{"key":"S1368980011003181_ref13","volume-title":"Guidelines for HIV Care and Treatment in Infants and Children","year":"2006"},{"key":"S1368980011003181_ref15","volume-title":"Antiretroviral Therapy for HIV Infection in Adults and Adolescents","year":"2010"},{"key":"S1368980011003181_ref11","volume-title":"WHO Global Database on Child Growth and Malnutrition","year":"1997"},{"key":"S1368980011003181_ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/837627"},{"key":"S1368980011003181_ref10","volume-title":"WHO Case Definitions for Surveillance and Revised Clinical Staging and Immunological Classification of HIV-Related Disease in Adults and Children","year":"2007"},{"key":"S1368980011003181_ref4","first-page":"45","article-title":"Prevalence of HIV infection and AIDS symptomatology in malnourished children \u2013 a hospital based study","volume":"36","author":"Angami","year":"2004","journal-title":"J Commun Dis"},{"key":"S1368980011003181_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-9-37"},{"key":"S1368980011003181_ref12","unstructured":"12. Centers for Disease Control and Prevention (2000) PedNSS Health Indicators. http:\/\/www.cdc.gov\/pedness\/what_is\/pedness_health_indicators.htm (accessed July 2010)."},{"key":"S1368980011003181_ref14","volume-title":"Nutrition in India. National Family Health Survey (NFHS-3), India, 2005\u201306","author":"Arnold","year":"2009"},{"key":"S1368980011003181_ref5","volume-title":"HIV\/AIDS: A Guide for Nutritional Care and Support","year":"2004"},{"key":"S1368980011003181_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2004.09.002"},{"key":"S1368980011003181_ref1","volume-title":"AIDS Epidemic Update 09","year":"2009"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980011003181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T15:17:12Z","timestamp":1556205432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980011003181\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,3]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S1368980011003181"],"URL":"https:\/\/doi.org\/10.1017\/s1368980011003181","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,3]]}}}