{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:08:46Z","timestamp":1780333726074,"version":"3.54.1"},"reference-count":63,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S136898001100334X_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B<jats:sub>12<\/jats:sub>and homocysteine and the 677C\u2192T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR).<\/jats:p><\/jats:sec><jats:sec id=\"S136898001100334X_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Case\u2013control study paired (1:1) on maternity clinic, date of birth and state of residence. Cases of anencephaly were identified using the Registry of the Mexican Neural Tube Defect Epidemiological Surveillance System. Case and control mothers were selected from the same maternity departments. All mothers completed a structured questionnaire and blood samples were obtained to determine the<jats:italic>MTHFR<\/jats:italic>677C\u2192T polymorphism and biochemical profile.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001100334X_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Mexico, Puebla and Guerrero states, Mexico.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001100334X_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>A total of 151 mothers of cases and controls were enrolled from March 2000 to February 2001. We had complete information on biochemical profile and<jats:italic>MTHFR<\/jats:italic>C677T polymorphism for ninety-eight mothers of cases and ninety-one mothers of controls.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001100334X_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The adjusted models show that the risk of anencephaly in mothers with 677TT genotype was reduced by 18 % (OR = 0\u00b782; 95 % CI 0\u00b772, 0\u00b794) for each 1 ng\/ml increment in serum folate. In terms of tertiles, mothers with 677TT genotype with serum folate levels in the upper tertile (&gt;14\u00b71 ng\/ml) had a 95 % lower risk to have a child with anencephaly than mothers with serum folate levels in the first and second tertiles (<jats:italic>P<\/jats:italic>trend = 0\u00b7012).<\/jats:p><\/jats:sec><jats:sec id=\"S136898001100334X_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Our data agree with the hypothesis of a gene\u2013nutrient interaction between<jats:italic>MTHFR<\/jats:italic>677C\u2192T polymorphism and folate status. We observed a protective effect on anencephaly risk only in mothers with 677TT genotype as serum folate levels increased.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s136898001100334x","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T11:46:59Z","timestamp":1326196019000},"page":"1419-1428","source":"Crossref","is-referenced-by-count":22,"title":["Effect on risk of anencephaly of gene\u2013nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B<sub>12<\/sub>and homocysteine profile"],"prefix":"10.1017","volume":"15","author":[{"given":"Marina","family":"Lacasa\u00f1a","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Blanco-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor 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