{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:49:46Z","timestamp":1783640986508,"version":"3.55.0"},"reference-count":60,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980013000864_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To assess the folate status of US women in a study of a folate-fortified oral contraceptive (OC) using the Short Folate Food Frequency Questionnaire and plasma and red blood cell (RBC) folate samples.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013000864_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Sub-analysis from a multi-centre, randomised, double-blind, controlled contraceptive trial with assessments at baseline and 6 months. We calculated dietary folate equivalents (DFE) consumed and the proportion of participants meeting folate adequacy benchmarks.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013000864_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Eight centres in the USA.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013000864_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Healthy women aged 18\u201340 years requesting contraception with no contraindications for OC use.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013000864_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Overall, 385 participants were randomised to either a novel folate-fortified OC or a marketed OC. The 262 (68 %) participants compliant with the protocol were included in the analysis set. Baseline daily DFE consumption was 529\u00b78 (<jats:sc>sd<\/jats:sc> 342\u00b71) \u03bcg and similar in both groups. At follow-up, the fortified OC group had higher intake than the conventional OC group (1225\u00b79 (<jats:sc>sd<\/jats:sc> 346\u00b72) \u03bcg compared with 500\u00b76 (<jats:sc>sd<\/jats:sc> 361\u00b72) \u03bcg). Mean plasma folate level increased from 44\u00b75 (<jats:sc>sd<\/jats:sc> 17\u00b72) to 55\u00b78 (<jats:sc>sd<\/jats:sc> 21\u00b71) nmol\/l. Mean RBC folate level increased from 996\u00b77 (<jats:sc>sd<\/jats:sc> 369\u00b78) to 1311\u00b79 (<jats:sc>sd<\/jats:sc> 436\u00b70) nmol\/l. The proportion meeting selected folate adequacy benchmarks increased in the fortified OC group (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013000864_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Lack of adequate folate intake in reproductive-aged women from dietary sources or supplements alone suggests the need for novel approaches. Use of folate-fortified OC ensures adequate folate levels and meeting of folate benchmarks.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980013000864","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T14:56:39Z","timestamp":1364396199000},"page":"1375-1383","source":"Crossref","is-referenced-by-count":7,"title":["The folate status of reproductive-aged women in a randomised trial of a folate-fortified oral contraceptive: dietary and blood assessments"],"prefix":"10.1017","volume":"17","author":[{"given":"Paula 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