{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:30:38Z","timestamp":1769920238993,"version":"3.49.0"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980013001742_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To investigate whether the recommended dietary intake of Ca in anaemic infants compromises the expected Hb response, via home fortification with a new Ca- and Fe-containing Sprinkles\u2122 micronutrient powder (MNP).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013001742_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>A double-blind, randomized controlled, 2-month trial was conducted in Bangladesh. Infants were randomized to one of two MNP intervention groups containing Fe and other micronutrients, with or without Ca. Hb, anthropometrics and dietary intake were measured pre- and post-intervention while family demographics were collected at baseline.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013001742_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Twenty-six rural villages in the Kaliganj sub-district of Gazipur, Bangladesh.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013001742_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>One hundred infants aged 6\u201311 months.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013001742_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>A significant increase in Hb (MNP, 13\u00b73 (<jats:sc>sd<\/jats:sc> 12\u00b76) g\/l <jats:italic>v<\/jats:italic>. Ca-MNP, 7\u00b76 (<jats:sc>sd<\/jats:sc> 11\u00b76) g\/l; <jats:italic>P<\/jats:italic> &lt; 0\u00b70001) was noted in infants from both groups. However, infants receiving MNP without Ca had a significantly higher end-point Hb concentration (<jats:italic>P<\/jats:italic> = 0\u00b7024) and rate of anaemia recovery (<jats:italic>P<\/jats:italic> = 0\u00b7008). Infants receiving MNP with Ca were more likely to remain anaemic (OR 3\u00b72; 95 % CI 1\u00b74, 7\u00b75). Groups did not differ in dietary intake or demographic and anthropometric indicators.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980013001742_abs6\" sec-type=\"conclusion\"><jats:title>Conclusions<\/jats:title><jats:p>Although both groups showed significant improvement in Hb status, the nutrient\u2013nutrient interaction between Fe and Ca may have diminished the Hb response in infants receiving the Ca-containing MNP.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980013001742","type":"journal-article","created":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T12:29:04Z","timestamp":1372768144000},"page":"1578-1586","source":"Crossref","is-referenced-by-count":9,"title":["Home fortification with calcium reduces Hb response to iron among anaemic Bangladeshi infants consuming a new multi-micronutrient powder formulation"],"prefix":"10.1017","volume":"17","author":[{"given":"Waqas Ullah","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohana","family":"Shafique","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasina","family":"Shikder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaseer Abdul","family":"Shakur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W","family":"Sellen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal S","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley H","family":"Zlotkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,7,2]]},"reference":[{"key":"S1368980013001742_ref24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ajcn\/87.4.929","article-title":"Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana","volume":"87","author":"Adu-Afarwuah","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"S1368980013001742_ref51","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/ajcn\/77.5.1229","article-title":"Erythrocyte protoporphyrin or hemoglobin: which is a better screening test for iron deficiency in children and women?","volume":"77","author":"Mei","year":"2003","journal-title":"Am J Clin Nutr"},{"key":"S1368980013001742_ref49","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.146316"},{"key":"S1368980013001742_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2008.01.007"},{"key":"S1368980013001742_ref40","first-page":"317","article-title":"Calcium and iron absorption: mechanism of action and nutritional importance","volume":"46","author":"Hallberg","year":"1992","journal-title":"Eur J Clin Nutr"},{"key":"S1368980013001742_ref38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jn\/131.2.649S","article-title":"A review of studies on the effect of iron deficiency on cognitive development in children","volume":"131","author":"Grantham-McGregor","year":"2001","journal-title":"J Nutr"},{"key":"S1368980013001742_ref29","doi-asserted-by":"publisher","DOI":"10.1177\/156482650702800204"},{"key":"S1368980013001742_ref34","doi-asserted-by":"crossref","first-page":"3011S","DOI":"10.1093\/jn\/133.9.3011S","article-title":"Proposed nutrient composition for fortified complementary foods","volume":"133","author":"Lutter","year":"2003","journal-title":"J Nutr"},{"key":"S1368980013001742_ref17","doi-asserted-by":"publisher","DOI":"10.1177\/156482650302400106"},{"key":"S1368980013001742_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/90.3.302"},{"key":"S1368980013001742_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-007-8053-z"},{"key":"S1368980013001742_ref33","volume-title":"Recommended Nutrient Intakes. 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