{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:57:35Z","timestamp":1758815855044},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T00:00:00Z","timestamp":1389657600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many studies have investigated the aetiological roles of genetic and environmental factors in coeliac disease (CD) with the long-term goal of developing an effective primary prevention strategy. CD is a condition with dysregulated systemic and intestinal mucosal immune responses to dietary gluten proteins among genetically predisposed individuals. We recently described spring birth as a novel risk factor for CD in children. We believe that the association between season of birth and CD is due to seasonal differences in sunlight exposure and subsequent vitamin D status. Concomitant with global increases in CD prevalence, vitamin D deficiency also is increasingly recognized in children worldwide. Recent studies have shown that vitamin D deficiency can cause improper immune responses, abnormal intestinal mucosal integrity and impaired local defence to pathogenic microbial agents. In conjunction with other potential aetiological factors, we propose a hypothesis model of early-life vitamin D deficiency in the pathogenesis of childhood-onset CD.<\/jats:p>","DOI":"10.1017\/s1368980013003510","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T16:10:25Z","timestamp":1389715825000},"page":"823-826","source":"Crossref","is-referenced-by-count":17,"title":["Early-life vitamin D deficiency and childhood-onset coeliac disease"],"prefix":"10.1017","volume":"17","author":[{"given":"Pornthep","family":"Tanpowpong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,1,14]]},"reference":[{"key":"S1368980013003510_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-009-0012-7"},{"key":"S1368980013003510_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10338"},{"key":"S1368980013003510_ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0442"},{"key":"S1368980013003510_ref23","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2158"},{"key":"S1368980013003510_ref13","doi-asserted-by":"publisher","DOI":"10.1136\/jech.57.1.36"},{"key":"S1368980013003510_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.2.218"},{"key":"S1368980013003510_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.056"},{"key":"S1368980013003510_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665111001650"},{"key":"S1368980013003510_ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.059"},{"key":"S1368980013003510_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22456"},{"key":"S1368980013003510_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06580-1"},{"key":"S1368980013003510_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(52)90795-2"},{"key":"S1368980013003510_ref4","doi-asserted-by":"publisher","DOI":"10.1080\/08916930802350789"},{"key":"S1368980013003510_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00365-11"},{"key":"S1368980013003510_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302360"},{"key":"S1368980013003510_ref6","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/ajcn\/75.5.914","article-title":"Breast-feeding protects against celiac disease","volume":"75","author":"Ivarsson","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"S1368980013003510_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181709530"},{"key":"S1368980013003510_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.03.050"},{"key":"S1368980013003510_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.001"},{"key":"S1368980013003510_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.19.2343"},{"key":"S1368980013003510_ref17","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00398.2007"},{"key":"S1368980013003510_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-69"},{"key":"S1368980013003510_ref22","doi-asserted-by":"publisher","DOI":"10.1186\/2042-6410-4-10"},{"key":"S1368980013003510_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00741.x"},{"key":"S1368980013003510_ref8","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.108530"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980013003510","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T22:22:23Z","timestamp":1555971743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980013003510\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,14]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1368980013003510"],"URL":"https:\/\/doi.org\/10.1017\/s1368980013003510","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,14]]}}}