{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:11:07Z","timestamp":1755925867383},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980014001475_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980014001475_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC\u2013tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980014001475_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Individuals born in Jerusalem during 1974\u20131976.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980014001475_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Participants of the Jerusalem Perinatal Study (<jats:italic>n<\/jats:italic> 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980014001475_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Mean total 25(OH)D concentration among participants was 21\u00b77 (<jats:sc>sd<\/jats:sc> 8\u00b79) ng\/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, <jats:italic>\u03b2<\/jats:italic>=\u22120\u00b7011, <jats:italic>P<\/jats:italic>=0\u00b7004) after adjustment for BMI. However, these associations were not present among females (<jats:italic>P<\/jats:italic> for sex interaction=0\u00b7005).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980014001475_abs6\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980014001475","type":"journal-article","created":{"date-parts":[[2014,8,22]],"date-time":"2014-08-22T11:44:09Z","timestamp":1408707849000},"page":"1324-1331","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":13,"title":["Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study"],"prefix":"10.1017","volume":"18","author":[{"given":"Amy","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Hochner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen 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