{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T17:40:04Z","timestamp":1691948404216},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980015002293_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>Fe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood\u2019s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980015002293_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>A population-based, cross-sectional study.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980015002293_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>National Nutrition and Health Survey in Taiwan (2010\u20132011, adolescents).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980015002293_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Healthy adolescents aged 13\u201318 years.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980015002293_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>In total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15\u00b73 (<jats:sc>sd<\/jats:sc>0\u00b71) years (boys, 15\u00b73 (<jats:sc>sd<\/jats:sc>0\u00b71) years; girls, 15\u00b72 (<jats:sc>sd<\/jats:sc>0\u00b71) years). ALT tertile cut-off points for boys were 11 and 16 U\/l, and for girls were 9 and 12 U\/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (&gt;13\u00b76 g\/dl) were 1\u00b789 and 3\u00b776 times more likely to have raised serum ALT (9 and &gt;12 U\/l, respectively) than the reference (lowest quartile of Hb (Q1), &lt;12\u00b74 g\/dl). Moreover, for those girls with dyslipidaemia, serum ALT seemed to increase with an increase in Hb levels. Specifically, girls with dyslipidaemia and Hb levels of 12\u00b74, 13\u00b71 and 13\u00b76 g\/dl were, respectively, 2\u00b786, 3\u00b753 and 5\u00b764 times more likely to have elevated serum ALT levels (&gt;12 U\/l) than the reference (Q1 of Hb, &lt;12\u00b74 g\/dl). The only effect found in boys was for those who had dyslipidaemia and presenting in Q4 of Hb (&gt;15\u00b74 g\/dl), who were 7\u00b740 times more likely to have elevated serum ALT of &gt;16 U\/l than the reference (Q1 of Hb, &lt;14\u00b71 g\/dl).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980015002293_abs6\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that an increased Hb level is a predictor of elevated serum ALT in adolescent girls with dyslipidaemia. Our study also highlights the importance of further research to establish cut-off points for Hb and its utility in diagnosing and preventing the onset of dyslipidaemia in adolescents.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980015002293","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T11:36:35Z","timestamp":1441193795000},"page":"1067-1073","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents"],"prefix":"10.1017","volume":"19","author":[{"given":"Kuo-Ching","family":"Chao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eddy","family":"Owaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyi-Huey","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-chieh","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Harn","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Su","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"S1368980015002293_ref25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4855"},{"key":"S1368980015002293_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws469"},{"key":"S1368980015002293_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080596"},{"key":"S1368980015002293_ref22","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.5.1182"},{"key":"S1368980015002293_ref29","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0944"},{"key":"S1368980015002293_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.008"},{"key":"S1368980015002293_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02597.x"},{"key":"S1368980015002293_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.10.010"},{"key":"S1368980015002293_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0203-y"},{"key":"S1368980015002293_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24097"},{"key":"S1368980015002293_ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2007.00434.x"},{"key":"S1368980015002293_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2014.02.021"},{"key":"S1368980015002293_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.08.043"},{"key":"S1368980015002293_ref32","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/BF02536204","article-title":"Effects of estrogen-induced hyperlipidemia on the erythrocyte membrane in chicks","volume":"23","author":"Cho","year":"1988","journal-title":"Lipids"},{"key":"S1368980015002293_ref7","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.045232"},{"key":"S1368980015002293_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26264"},{"key":"S1368980015002293_ref34","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0022-2275(20)38181-5","article-title":"Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease","volume":"23","author":"Owen","year":"1982","journal-title":"J Lipid Res"},{"key":"S1368980015002293_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.09.060"},{"key":"S1368980015002293_ref5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/ajcn\/82.5.1046","article-title":"Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents","volume":"82","author":"Park","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"S1368980015002293_ref33","doi-asserted-by":"crossref","first-page":"C423","DOI":"10.1152\/ajpcell.1991.261.3.C423","article-title":"Estrogen modulates phospholipid acylation in red blood cells: relationship to cell aging","volume":"261","author":"Le Petit-Thevenin","year":"1991","journal-title":"Am J Physiol"},{"key":"S1368980015002293_ref8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ajcn\/88.1.16","article-title":"Relation between alanine aminotransferase concentrations and visceral fat accumulation among nondiabetic overweight Korean women","volume":"88","author":"Song","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"S1368980015002293_ref30","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22306"},{"key":"S1368980015002293_ref26","doi-asserted-by":"publisher","DOI":"10.3390\/nu6093929"},{"key":"S1368980015002293_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.meatsci.2011.04.025"},{"key":"S1368980015002293_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.05.027"},{"key":"S1368980015002293_ref28","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.17.9982"},{"key":"S1368980015002293_ref36","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25988"},{"key":"S1368980015002293_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.ndt.a027970"},{"key":"S1368980015002293_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2047-6310.2013.00199.x"},{"key":"S1368980015002293_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2011.04.004"},{"key":"S1368980015002293_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2008.00464.x"},{"key":"S1368980015002293_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90331-R"},{"key":"S1368980015002293_ref3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.47102\/annals-acadmedsg.V38N1p15","article-title":"The risk factors for ultrasound-diagnosed non-alcoholic fatty liver disease among adolescents","volume":"38","author":"Fu","year":"2009","journal-title":"Ann Acad Med Singapore"},{"key":"S1368980015002293_ref35","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12580"},{"key":"S1368980015002293_ref13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4745"},{"key":"S1368980015002293_ref15","doi-asserted-by":"publisher","DOI":"10.4077\/CJP.2014.BAD280"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980015002293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T16:58:10Z","timestamp":1691945890000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980015002293\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,2]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["S1368980015002293"],"URL":"https:\/\/doi.org\/10.1017\/s1368980015002293","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"value":"1368-9800","type":"print"},{"value":"1475-2727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,2]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}