{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:06:44Z","timestamp":1785859604786,"version":"3.56.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S136898001500244X_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To examine the relationship between dietary cruciferous vegetable intake and selected tumour biomarkers for histone acetylation (H3K9ac, H3K18ac, HDAC3 and HDAC6), proliferation (Ki-67) and cell-cycle regulation (p21) from breast tissue.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001500244X_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>The study used baseline data of women recruited to participate in a clinical trial of sulforaphane supplement. Dietary cruciferous vegetable intake was collected through a validated Arizona Cruciferous Vegetable Intake Questionnaire. Breast tissue was obtained from biopsy samples. Spearman correlations were calculated between intake of specific cruciferous vegetables and biomarkers. Tissue biomarkers were log<jats:sub>2<\/jats:sub>-transformed to obtain approximate normality. Linear regression analyses were conducted to examine associations between cruciferous vegetable intake and biomarkers adjusting for age and use of non-steroidal anti-inflammatory drugs. False discovery rate (FDR) was used to account for multiple comparisons.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001500244X_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Clinical trial baseline.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001500244X_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Fifty-four women who had abnormal mammogram findings and were scheduled for breast biopsy.<\/jats:p><\/jats:sec><jats:sec id=\"S136898001500244X_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Mean intake of total cruciferous vegetables from all food sources was 81\u00b77 (<jats:sc>sd<\/jats:sc>57\u00b73) g\/d. Mean urinary total sulforaphane metabolites was 0\u00b708 (<jats:sc>sd<\/jats:sc>0\u00b707) \u00b5<jats:sc>m<\/jats:sc>\/m<jats:sc>m<\/jats:sc>creatinine. Total cruciferous vegetable intake was inversely associated with Ki-67 protein expression in breast ductal carcinoma<jats:italic>in situ<\/jats:italic>(DCIS) tissue (<jats:italic>\u03b2<\/jats:italic>=\u22120\u00b7004;<jats:sc>se<\/jats:sc>=0\u00b7001; FDR<jats:italic>q<\/jats:italic>value=0\u00b703), but not in benign or invasive ductal carcinoma (IDC) tissue. No association was found for other biomarkers measured (HDAC3, HDAC6, H3K9, H3K18 and p21) in all tissues examined (benign, DCIS and IDC).<\/jats:p><\/jats:sec><jats:sec id=\"S136898001500244X_abs6\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>The present study sought to provide additional evidence for the potential role of sulforaphane in histone acetylation and cell proliferation. Here, we report that total cruciferous vegetable intake is associated with decreased cell proliferation in breast DCIS tissue.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s136898001500244x","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T11:36:29Z","timestamp":1441193789000},"page":"1288-1295","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Associations between cruciferous vegetable intake and selected biomarkers among women scheduled for breast biopsies"],"prefix":"10.1017","volume":"19","author":[{"given":"Zhenzhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren L","family":"Atwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige E","family":"Farris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackilen","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,2]]},"reference":[{"key":"S136898001500244X_ref28","first-page":"501","article-title":"Chemoprotective glucosinolates and isothiocyanates of broccoli sprouts: metabolism and excretion in humans","volume":"10","author":"Shapiro","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"S136898001500244X_ref18","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3907"},{"key":"S136898001500244X_ref26","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-085-3"},{"key":"S136898001500244X_ref4","first-page":"6861","article-title":"The role of dietary factors in prevention and progression of breast cancer","volume":"34","author":"Rossi","year":"2014","journal-title":"Anticancer Res"},{"key":"S136898001500244X_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-007-0676-5"},{"key":"S136898001500244X_ref9","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/jn\/130.12.3063","article-title":"More Americans are eating \u20185 a day\u2019 but intakes of dark green and cruciferous vegetables remain low","volume":"130","author":"Johnston","year":"2000","journal-title":"J Nutr"},{"key":"S136898001500244X_ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Statist Soc B"},{"key":"S136898001500244X_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000547"},{"key":"S136898001500244X_ref3","first-page":"34S","article-title":"Complementary and alternative medicine use among women with breast cancer","volume":"20","author":"DiGianni","year":"2002","journal-title":"J Clinl Oncol"},{"key":"S136898001500244X_ref14","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-06-0494"},{"key":"S136898001500244X_ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"S136898001500244X_ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.19.10367"},{"key":"S136898001500244X_ref5","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.3.1291"},{"key":"S136898001500244X_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2013.12.019"},{"key":"S136898001500244X_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980014001505"},{"key":"S136898001500244X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2012.07.013"},{"key":"S136898001500244X_ref10","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.009340"},{"key":"S136898001500244X_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm141"},{"key":"S136898001500244X_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.01.016"},{"key":"S136898001500244X_ref7","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.3.1565"},{"key":"S136898001500244X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2011.07.005"},{"key":"S136898001500244X_ref16","volume-title":"USDA Food and Nutrient Database for Dietary Studies","year":"2011"},{"key":"S136898001500244X_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.769"},{"key":"S136898001500244X_ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2399"},{"key":"S136898001500244X_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.08.025"},{"key":"S136898001500244X_ref2","volume-title":"Breast Cancer Facts and Figures 2013\u20132014","year":"2013"},{"key":"S136898001500244X_ref19","first-page":"716","article-title":"Estrogen receptor analyses. 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