{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:42:35Z","timestamp":1785368555797,"version":"3.55.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"17","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980016001415_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980016001415_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>BMI categories were calculated among postmenopausal women who reported their weight and height at age 18 years. Multiple-variable logistic regression was used to determine the association between BMI at age 18 years and BMI transitions over adulthood on severe physical impairment (SPI), defined as scoring &lt;60 on the Physical Functioning subscale of the Rand thirty-six-item Short-Form Health Survey.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980016001415_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Participants were part of the Women\u2019s Health Initiative Observational Study (WHI OS), where participants\u2019 health was followed over time via questionnaires and clinical assessments.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980016001415_abs4\" sec-type=\"subjects\"><jats:title>Subjects<\/jats:title><jats:p>Postmenopausal women (<jats:italic>n<\/jats:italic>76 016; mean age 63\u00b75 (<jats:sc>sd<\/jats:sc>7\u00b73) years).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980016001415_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>Women with overweight (BMI=25\u00b70\u201329\u00b79 kg\/m<jats:sup>2<\/jats:sup>) or obesity (BMI\u226530\u00b70 kg\/m<jats:sup>2<\/jats:sup>) at 18 years had greater odds (OR (95 % CI)) of SPI (1\u00b751 (1\u00b735, 1\u00b769) and 2\u00b714 (1\u00b772, 2\u00b765), respectively) than normal-weight (BMI=18\u00b75\u201324\u00b79 kg\/m<jats:sup>2<\/jats:sup>) counterparts. Transitions from normal weight to overweight\/obese or to underweight (BMI&lt;18\u00b75 kg\/m<jats:sup>2<\/jats:sup>) were associated with greater odds of SPI (1\u00b797 (1\u00b784, 2\u00b711) and 1\u00b735 (1\u00b706, 1\u00b771), respectively) compared with weight stability. Shifting from underweight to overweight\/obese also had increased odds of SPI (1\u00b752 (1\u00b711, 2\u00b709)). Overweight\/obese to normal BMI transitions resulted in a reduced SPI odds (0\u00b752 (0\u00b739, 0\u00b771)).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980016001415_abs6\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>Higher weight history and transitions into higher weight classes were associated with higher likelihood of SPI, while transitioning into lower weight classes for those with overweight\/obesity was protective among postmenopausal women.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980016001415","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T10:52:43Z","timestamp":1465383163000},"page":"3169-3177","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Physical impairment and body weight history in postmenopausal women: the Women\u2019s Health Initiative"],"prefix":"10.1017","volume":"19","author":[{"given":"Amal 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