{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:46:18Z","timestamp":1777524378555,"version":"3.51.4"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Public Health Nutr."],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980019000193_abs1\" sec-type=\"general\"><jats:title>Objective<\/jats:title><jats:p>To assess the nutritional status of folate and vitamin B<jats:sub>12<\/jats:sub> with anaemia in young children.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019000193_abs2\" sec-type=\"general\"><jats:title>Design<\/jats:title><jats:p>A cross-sectional study was conducted at the primary health-care centres of four Brazilian cities. Folate and vitamin B<jats:sub>12<\/jats:sub> were assessed by fluoroimmunoassay. Multilevel Poisson regression models were used to explore the association of folate and vitamin B<jats:sub>12<\/jats:sub> status in relation to anaemia in young children.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019000193_abs3\" sec-type=\"general\"><jats:title>Setting<\/jats:title><jats:p>Brazil.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019000193_abs4\" sec-type=\"general\"><jats:title>Participants<\/jats:title><jats:p>Children (<jats:italic>n<\/jats:italic> 460) aged 11 to 15 months.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019000193_abs5\" sec-type=\"results\"><jats:title>Results<\/jats:title><jats:p>The median (interquartile range) of serum folate was 39\u00b77 (28\u00b78\u201355\u00b73) nmol\/l and only four children presented with folate deficiency (&amp;lt;10 nmol\/l). Surprisingly, 30\u00b79 % of children presented with serum folate concentrations above the upper limit of detectable values by the commercial kit used for analysis. The frequency of vitamin B<jats:sub>12<\/jats:sub> deficiency (&amp;lt;148 pmol\/l) was 15 % and it was inversely associated with the highest tertile of serum folate concentrations (<jats:italic>P<\/jats:italic>&amp;lt;0\u00b7001). Having high serum folate concentration (\u226550\u00b71 nmol\/l) and vitamin B<jats:sub>12<\/jats:sub>\u2265148 pmol\/l was associated with lower frequency of anaemia in these children (prevalence ratio=0\u00b753; 95% CI 0\u00b730, 0\u00b792).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019000193_abs6\" sec-type=\"conclusions\"><jats:title>Conclusions<\/jats:title><jats:p>High frequency of elevated serum concentration of folate was found among young Brazilian children and 15 % of them had vitamin B<jats:sub>12<\/jats:sub> deficiency. The combination of high serum folate and normal vitamin B<jats:sub>12<\/jats:sub> status was associated with a lower frequency of anaemia in these children. Improvements in the current strategies to promote healthy food-based complementary feeding along with prevention and control of micronutrient deficiencies are recommended to improve children\u2019s health.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980019000193","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T02:25:51Z","timestamp":1551407151000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Serum folate and vitamin B12 status in young Brazilian children"],"prefix":"10.1017","author":[{"given":"Lara LS","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaie W","family":"Fawzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marly A","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the ENFAC Working Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,3,1]]},"reference":[{"key":"S1368980019000193_ref31","volume-title":"Serum and Red Blood Cell Folate Concentrations for Assessing Folate Status in Populations","year":"2012"},{"key":"S1368980019000193_ref30","first-page":"354","volume":"92","year":"2013","journal-title":"Eur J Haematol"},{"key":"S1368980019000193_ref19","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"S1368980019000193_ref18","doi-asserted-by":"publisher","DOI":"10.3109\/17477161003615583"},{"key":"S1368980019000193_ref17","volume-title":"WHO Child Growth Standards: Length\/Height-for-Age, Weight-for-Age, Weight-for-Length, Weight-for-Height and Body Mass Index-for-Age: Methods and Development","year":"2006"},{"key":"S1368980019000193_ref16","volume-title":"Anthropometric Standardization Reference Manual","year":"1988"},{"key":"S1368980019000193_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151097"},{"key":"S1368980019000193_ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-015-0006-3"},{"key":"S1368980019000193_ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.50"},{"key":"S1368980019000193_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9119-1"},{"key":"S1368980019000193_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2016.11.004"},{"key":"S1368980019000193_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.7.1391"},{"key":"S1368980019000193_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2016.04.010"},{"key":"S1368980019000193_ref6","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-36342012000200007"},{"key":"S1368980019000193_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2014.03.018"},{"key":"S1368980019000193_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu9010072"},{"key":"S1368980019000193_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980014003061"},{"key":"S1368980019000193_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13579"},{"key":"S1368980019000193_ref3","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S105"},{"key":"S1368980019000193_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S103"},{"key":"S1368980019000193_ref1","doi-asserted-by":"publisher","DOI":"10.4103\/2394-2010.143318"},{"key":"S1368980019000193_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.2.433"},{"key":"S1368980019000193_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdv087"},{"key":"S1368980019000193_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516002695"},{"key":"S1368980019000193_ref26","doi-asserted-by":"publisher","DOI":"10.3390\/nu3030370"},{"key":"S1368980019000193_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.5.1307"},{"key":"S1368980019000193_ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036341"},{"key":"S1368980019000193_ref23","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29284"},{"key":"S1368980019000193_ref22","volume-title":"Iron Deficiency Anaemia: Assessment, Prevention and Control. 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