{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:37:19Z","timestamp":1759991839565,"version":"3.40.5"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980019004178_as1\" sec-type=\"other\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to analyse the relationship between vitamin D deficiency and the season when the blood sample was obtained from subjects with chronic hepatitis C (CHC) infection.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004178_as2\" sec-type=\"other\"><jats:title>Design:<\/jats:title><jats:p>A cross-sectional study was conducted on a representative sample. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration &lt;50\u00a0nmol\/l, based on the values set forth by the Endocrine Society guideline for higher-risk populations. Seasonality was defined according to solstices and equinoxes. The association of seasonality and clinical\/laboratory characteristics with vitamin D deficiency was assessed using a multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004178_as3\" sec-type=\"other\"><jats:title>Setting:<\/jats:title><jats:p>NUPAIG Viral Hepatitis Outpatient Clinic of the Universidade Federal de S\u00e3o Paulo \u2013 Brazil.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004178_as4\" sec-type=\"other\"><jats:title>Participants:<\/jats:title><jats:p>Adult subjects with CHC infection (<jats:italic>n<\/jats:italic> 306).<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004178_as5\" sec-type=\"other\"><jats:title>Results:<\/jats:title><jats:p>The prevalence of vitamin D deficiency was 16\u00a0%, whereas the median serum 25(OH)D concentration was 87 (interquartile range, 59; third quartile\u00a0=\u00a0118) nmol\/l. Serum concentration was consistently lower in samples collected in spring and winter than in other seasons. In multivariate analysis, vitamin D deficiency was found to be independently associated with male gender, serum albumin concentration and with samples drawn in winter and spring.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004178_as6\" sec-type=\"other\"><jats:title>Conclusions:<\/jats:title><jats:p>The findings show not only the relevance to consider season as a factor influencing 25(OH)D concentration but also the need to actively screen for hypovitaminosis D in all patients with CHC infection, especially in females and those with low albumin concentration.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980019004178","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T10:10:09Z","timestamp":1583748609000},"page":"1247-1253","source":"Crossref","is-referenced-by-count":5,"title":["Association of seasonality and serum albumin concentration with vitamin D deficiency in subjects with chronic hepatitis C infection living in a sunny country"],"prefix":"10.1017","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3126-2946","authenticated-orcid":false,"given":"Henrique","family":"Pott-Junior","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila","family":"Luzeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Figueiredo","family":"Senise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adauto","family":"Castelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"doi-asserted-by":"publisher","key":"S1368980019004178_ref22","DOI":"10.1111\/liv.12147"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref21","DOI":"10.1038\/s41598-017-09512-7"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref18","DOI":"10.1002\/cbf.2835"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref15","DOI":"10.1007\/s00198-013-2366-x"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref14","DOI":"10.1590\/0004-2730000003388"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref9","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref4","DOI":"10.1515\/jomb-2015-0014"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref3","DOI":"10.1016\/S1665-2681(19)31166-4"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref2","DOI":"10.1016\/j.ijid.2017.07.026"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref12","DOI":"10.1002\/jcla.21793"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref1","DOI":"10.1097\/MEG.0000000000001134"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref8","DOI":"10.1002\/hep.24105"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref13","DOI":"10.1210\/jc.2011-0385"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref11","DOI":"10.1093\/ajcn\/88.2.511S"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref5","DOI":"10.1111\/nbu.12349"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref16","DOI":"10.1359\/jbmr.081209"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref20","DOI":"10.1016\/j.biopha.2018.10.140"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref6","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref10","DOI":"10.1373\/clinchem.2004.031831"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref19","DOI":"10.3390\/nu10111656"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref17","DOI":"10.1007\/s00198-015-3296-6"},{"doi-asserted-by":"publisher","key":"S1368980019004178_ref7","DOI":"10.7326\/0003-4819-158-11-201306040-00005"}],"container-title":["Public Health Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S1368980019004178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T13:54:52Z","timestamp":1587131692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S1368980019004178\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,9]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S1368980019004178"],"URL":"https:\/\/doi.org\/10.1017\/s1368980019004178","relation":{},"ISSN":["1368-9800","1475-2727"],"issn-type":[{"type":"print","value":"1368-9800"},{"type":"electronic","value":"1475-2727"}],"subject":[],"published":{"date-parts":[[2020,3,9]]}}}