{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T15:58:22Z","timestamp":1772639902922,"version":"3.50.1"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"16","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Nutr."],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S1368980019004580_as1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the association of folic acid (FA) supplementation with birth weight, the risk of small for gestational age (SGA) and low birth weight (LBW) in singleton and twin pregnancy.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004580_as2\"><jats:title>Design:<\/jats:title><jats:p>A population-based cross-sectional survey.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004580_as3\"><jats:title>Setting:<\/jats:title><jats:p>Twenty counties and ten districts in Shaanxi Province of northwestern China, 2013.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004580_as4\"><jats:title>Participants:<\/jats:title><jats:p>28\u00a0174 pregnant women with their infants, covering 27\u00a0818 single live births and 356 twin live births.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004580_as5\"><jats:title>Results:<\/jats:title><jats:p>The prevalence of FA supplementation in singletons and twins was 63\u00b79 and 66\u00b73 %. The mean birth weight was 3267 (<jats:sc>sd<\/jats:sc> 459\u00b71) g, 2525 (<jats:sc>sd<\/jats:sc> 534\u00b70) g and 2494 (<jats:sc>sd<\/jats:sc> 539\u00b75) g; the prevalence of SGA was 14\u00b73, 51\u00b74 and 53\u00b74 %; the prevalence of LBW was 3\u00b74, 42\u00b74 and 46\u00b76 % among singleton, twin A and twin B, respectively. Compared with non-users, women with FA supplementation were (<jats:italic>\u03b2<\/jats:italic> 17\u00b73, 95 % CI 6\u00b71, 28\u00b74; <jats:italic>\u03b2<\/jats:italic> 166\u00b73, 95 % CI 69\u00b71, 263\u00b75) associated with increased birth weight, lower risk of SGA (OR 0\u00b785, 95 % CI 0\u00b780, 0\u00b792; OR 0\u00b745, 95 % CI 0\u00b730, 0\u00b768) and LBW (OR 0\u00b782, 95 % CI 0\u00b771, 0\u00b795; OR 0\u00b750, 95 % CI 0\u00b733, 0\u00b775) in singletons and twins, and more prominent effects in twins. Moreover, there were significant interactions between FA supplementation and plurality on birth weight, SGA and LBW.<\/jats:p><\/jats:sec><jats:sec id=\"S1368980019004580_as6\"><jats:title>Conclusions:<\/jats:title><jats:p>The present study suggests the association of periconceptional 0\u00b74 mg\/d FA supplementation with increased birth weight and reduced risk of SGA and LBW in both singletons and twins, and this association may be more prominent in twins.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s1368980019004580","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T10:46:40Z","timestamp":1587120400000},"page":"2973-2982","source":"Crossref","is-referenced-by-count":12,"title":["Maternal folic acid supplementation and more prominent birth weight gain in twin birth compared with singleton birth: a cross-sectional study in northwest China"],"prefix":"10.1017","volume":"23","author":[{"given":"Binyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhang","family":"Shang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baibing","family":"Mi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoshuai","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaonong","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"key":"S1368980019004580_ref38","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-11-42"},{"key":"S1368980019004580_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-012-0339-z"},{"key":"S1368980019004580_ref30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010806"},{"key":"S1368980019004580_ref29","first-page":"97","article-title":"Chinese neonatal birth weight curve for different gestational age","volume":"2","author":"Zhu","year":"2015","journal-title":"Chin J Pediatr"},{"key":"S1368980019004580_ref3","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1001\/jama.2008.886","article-title":"Birth weight and risk of type 2 diabetes: a systematic review","volume":"300","author":"Whincup","year":"2008","journal-title":"JAMA"},{"key":"S1368980019004580_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904223401603"},{"key":"S1368980019004580_ref13","unstructured":"13. 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